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International Journal of Endocrinology
Volume 2016, Article ID 2383216, 11 pages
http://dx.doi.org/10.1155/2016/2383216
Research Article

Polymorphisms of Vitamin D Signaling Pathway Genes and Calcium-Sensing Receptor Gene in respect to Survival of Hemodialysis Patients: A Prospective Observational Study

1Chair and Department of Nephrology, Transplantology and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, Poland
2Student Nephrology Research Group, Chair and Department of Nephrology, Transplantology and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, Poland
3Chair and Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Święcickiego 6, 60-781 Poznań, Poland
4Chair and Department of Biophysics, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland

Received 27 April 2016; Revised 27 June 2016; Accepted 23 July 2016

Academic Editor: Xiangbing Wang

Copyright © 2016 Alicja E. Grzegorzewska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The Supplementary Material contains characteristics of the analyzed polymorphisms and conditions for their identification (Supplementary Tables 1-2), associations of vitamin D signaling pathway genes and CASR with infection-related and neoplasm-related mortalities (Supplementary Tables 3-4), characteristics of patients in respect to GC rs2298849 and VDR rs2228570 polymorphic variants (Supplementary Tables 5-6), haplotype frequencies in patients who died on HD and those who survived on HD for 7 years in respect to all-cause and cardiovascular mortality (Supplementary Tables 7-8), epistatic interactions between genes in patients who died on HD and those who survived on HD for 7 years in respect to all-cause and cardiovascular mortality (Supplementary Tables 9-10), and haplotype frequencies and epistatic interactionsbetweengenes in dyslipidemic HD patients and non-dyslipidemic HD subjects(Supplementary Table 11-12). Cumulative proportion surviving curves are presented for cardiovascular, infection-related and neoplasm-related mortalities in hemodialysis patients in respect to GC rs2298849 polymorphism (Supplementary Figures 1-3) as well as in respect to circulating 25(OH)D at the start of the prospective study (Supplementary Figure 4).

  1. Supplementary Material