Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature

Table 2

Polymorphisms of clock genes associated with infertility and mood disorders.

Gene	SNPs	Variation	Localization	Pathology	Reference
Clock	rs1801260	T>C	Chromosome 4; 3′ UTR; Homo sapiens	Bipolar disease	[66]
	rs11932595	A>G	Chromosome 4; intron; Homo sapiens	Infertility and bipolar disease	[31, 66]
	rs6811520	T>C	Chromosome 4; intron; Homo sapiens	Infertility	[31]
	rs6850524	G>C	Chromosome 4; intron; Homo sapiens	Infertility	[31]
Per2	rs56013859	T>C	Chromosome 2; intron; Homo sapiens	Alcohol intake	[34]
Per3	rs57875989	Deletion/insertion	Chromosome 1; 5′ near gene; Homo sapiens	Bipolar disease	[67, 68]
	rs2859387	G>A/C	Chromosome 1; 5′ near gene; Homo sapiens	Bipolar disease	[69]
Bmal1	rs4757144	G>A	Chromosome 11; intron; Homo sapiens	Infertility and bipolar disease	[31, 69]
	rs1481892	G>C	Chromosome 11; intron; Homo sapiens	Bipolar disease	[69]
	rs1982350	A>G	Chromosome 11; intron; Homo sapiens	Bipolar disease	[69]
	rs2279287	T>C	Chromosome 11; near-Gene 5′; Homo sapiens	Seasonal affective disorder	[70]
Cry1	rs2287161	G>C	Chromosome 12; upstream variant 2 KB; Homo sapiens	Depression disease	[30]
Cry2	rs4132063	C>T	Chromosome 11; Homo sapiens	Depression disease	[71]
	rs10838524	A>G	Chromosome 11; Homo sapiens	Depression disease	[71]
Tef	rs738499	G>T	Chromosome 22; intron upstream variant 2 KB; Homo sapiens	Depression disease	[30]
TIM	rs2291739	G>A/C	Chromosome 12; exon; Homo sapiens	Unipolar disease	[66]
	rs11171856	C>T	Chromosome 12; intron; Homo sapiens	Unipolar disease	[66]