Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature

Table 3

Polymorphisms of clock genes associated with cancer.

Gene	SNPs	Variation	Localization	Pathology	Reference
Clock	rs1801260	T>C	Chromosome 4; 3′ UTR; Homo sapiens	Colorectal cancer	[32]
	rs11932595	A>G	Chromosome 4; intron; Homo sapiens	Breast cancer	[72]
	rs7698022	C>A	Chromosome 4; intron; Homo sapiens	Breast cancer	[73]
	rs11932595	A>G	Chromosome 4; intron; Homo sapiens	Breast cancer	[73]
	rs1048004	G>T	Chromosome 4; 3′ UTR; Homo sapiens	Breast cancer	[73]
	rs3805151	C>T	Chromosome 4; intron-6; Homo sapiens	Breast cancer	[74]
	rs11133391	T>C	Chromosome 4; intron; Homo sapiens	Glioma	[75]
Per1	rs2585405	C>G	Chromosome 17; missense; Homo sapiens	Glioma	[75]
	rs2289591	G>T	Chromosome 17; 5′ near gene; Homo sapiens	Prostate cancer	[76]
Per2	rs7602358	G>T	Chromosome 2; intron; Homo sapiens	Prostate cancer	[76]
	rs934945:	G>A	Chromosome 2; Exon-23; Homo sapiens	Breast cancer	[74]
Per3	rs1012477	G>C	Chromosome 1; 5′ near gene; Homo sapiens	Prostate cancer	[76]
	rs57875989	Deletion/insertion	Chromosome 1; 5′ near gene; Homo sapiens	Colorectal cancer, breast cancer; Prostate cancer	[74, 77–81]
	rs228669	T>C	Chromosome 1; CDS; Homo sapiens	Hepatocellular carcinoma	[82]
	rs228644	G>A	Chromosome 1; intron; Homo sapiens	Lung cancer	[83]
Bmal1	rs2290035	T>A	Chromosome 11; intron; Homo sapiens	Breast cancer	[84]
	rs969485	G>A	Chromosome 11; intron; Homo sapiens	Breast cancer	[84]
Cry1	rs3809236	C>T	Chromosome 12; 5′ UTR Homo sapiens	Hepatocellular carcinoma	[82]
	rs1056560	T>G	Chromosome 12; exon-13 Homo sapiens	Breast cancer	[74]
	rs7297614	C>T	Chromosome 12; 5′ UTR Homo sapiens	Prostate cancer	[85]
	rs1921126	C>T	Chromosome 12; intron Homo sapiens	Prostate cancer	[85]
	rs12315175	T>C	Chromosome 12; 5′ UTR Homo sapiens	Prostate cancer	[85]
	rs12315175	T>C	Chromosome 12; noncoding sequence	Glioma	[75]
Cry2	rs11038689	A>G	Chromosome 11; intron; Homo sapiens	Breast cancer	[84]
	rs1401417	C>G	Chromosome 11; intron; Homo sapiens	Breast cancer; Prostate cancer	[79, 84]
	rs11038689	A>G	Chromosome 11; intron; Homo sapiens	Non-Hodgkin’s lymphoma	[86]
	rs7123390	G>A	Chromosome 11; intron; Homo sapiens	Non-Hodgkin’s lymphoma	[86]
	rs1401417	C>G	Chromosome 11; intron; Homo sapiens	Non-Hodgkin’s lymphoma	[86]
TIM	rs7302060	T>C	Chromosome 12; intron; Homo sapiens	Breast cancer	[87]
	rs2291738	T>C	Chromosome 12; intron; Homo sapiens	Breast cancer	[87]
ROR-b	rs3750420	C>T	Chromosome 9; intron; Homo sapiens	Breast cancer	[84]
	rs3903529	T>A	Chromosome 9; intron; Homo sapiens	Breast cancer	[84]