Different Effects of Myoinositol plus Folic Acid versus Combined Oral Treatment on Androgen Levels in PCOS Women

Table 3

Comparison of changes in all parameters after treatment between the groups.

	GROUP 1-COC; ()			GROUP 2-MYO; ()
	Month 0	Month 3		Month 0	Month 3
BMI (kg/m^2)			0.166			0.656
WHR			0.175			0.230
Ferriman Gallwey score			<0.001			0.859
Fasting glucose (mg/dL)			0.990			0.028
Fasting insulin (μIU/dL)			0.521			0.531
HOMA-IR			0.633			0.527
HDL (mg/dL)			0.016			0.870
LDL (mg/dL)			0.102			0.031
TG (mg/dL)			0.554			0.703
Total cholesterol (mg/dL)			0.822			0.200
DHEAS (μg/dL)			0.492			0.043
C-peptide (ng/mL)			0.770			0.220
Total testosterone (ng/dL)			0.826			<0.001
Free testosterone (pg/mL)			0.153			0.460
Androstenedione (ng/mL)			0.098			0.870
SHBG (nmol/L)			0.030			0.479
Progesterone (ng/mL)			0.014			<0.001
Estradiol (pg/mL)			0.051			0.635
FSH (mIU/mL)			0.246			0.397
LH (mIU/mL)			<0.001			0.680
LH/FSH ratio			<0.001			0.146
Prolactin (ng/mL)			0.370			0.001
TSH (μU/mL)			0.481			0.124
AMH (ng/mL)			<0.001			0.002
Right ovary volume (cm^3)			<0.001			<0.001
Left ovary volume (cm^3)			<0.001			<0.001
Total ovary volume (cm^3)			<0.001			<0.001
Right ovary follicle count			<0.001			<0.001
Left ovary follicle count			<0.001			<0.001
Total antral follicle count			<0.001			<0.001

COC: combined oral contraceptives; MYO: myoinositol + folic acid; BMI: body mass index; WHR: waist hip ratio; HOMA-IR: Homeostatic Model Assessment-Insulin Resistance; HDL: high density lipoprotein; LDL: low density lipoprotein; TG: triglyceride; DHEAS: dehydroepiandrosterone sulfate; SHBG: sex hormone binding globulin; FSH: follicular stimulating hormone; LH: luteinizing hormone; TSH: thyroid stimulating hormone; AMH: anti-Mullerian hormone. Paired samples test.