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International Journal of Endocrinology
Volume 2016, Article ID 4658469, 9 pages
http://dx.doi.org/10.1155/2016/4658469
Research Article

The Association between Treatment for Metabolic Disorders and Breast Cancer Characteristics

1Institute of Oncology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski St., Petah Tikva, Israel
2Sackler Faculty of Medicine, Tel Aviv University, P.O. Box 39040, Tel Aviv, Israel
3Department of Medicine A, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski St., Petah Tikva, Israel
4Statistical Consulting Unit, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski St., Petah Tikva, Israel

Received 17 March 2016; Revised 16 July 2016; Accepted 9 August 2016

Academic Editor: Andrea Tura

Copyright © 2016 Hadar Goldvaser et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To evaluate the associations between metformin, insulin, statins, and levothyroxine and breast cancer characteristics and outcome. Methods. Retrospective chart review of patients treated in our institute for early estrogen receptor (ER) positive, human epidermal growth factor receptor 2 negative breast cancer, whose tumors were sent to Oncotype DX (ODX) analysis. Patients were grouped according to medications usage during the time of breast cancer diagnosis. Each group was compared to the rest of the study population. Results. The study cohort included 671 patients. Sixty (9.1%) patients were treated with metformin, 9 (1.4%) with insulin, 208 (31.7%) with statins, and 62 (9.4%) with levothyroxine. Patients treated with metformin had more intense ER stain () and a lower ODX recurrence score (RS) (). Diagnosis of diabetes mellitus was also associated with lower ODX RS (). Insulin usage was associated with a higher rate of angiolymphatic invasion (), but lower Ki67% (). Levothyroxine usage was associated with different histological subtype distribution (). Extended levothyroxine usage was associated with lower ODX RS (). Statin usage had no impact on tumor characteristics. Outcome was comparable in the studied subgroups. Conclusions. Common medications for metabolic disorders might be associated with breast cancer characteristics.