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International Journal of Endocrinology
Volume 2016, Article ID 4802720, 8 pages
Research Article

Thyroid Stimulating Hormone Is Increased in Hypertensive Patients with Obstructive Sleep Apnea

The Center for Hypertension of the People’s Hospital of Xinjiang Uygur Autonomous Region, The Center for Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91, TianChi Road, Urumqi, Xinjiang 830001, China

Received 11 April 2016; Revised 7 September 2016; Accepted 22 September 2016

Academic Editor: Javier Salvador

Copyright © 2016 Nanfang Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To evaluate alteration in serum TSH in hypertensives with OSA and its relation with cardiometabolic risk factors. Methods. 517 hypertensives were cross-sectionally studied. OSA was determined by polysomnography and thyroid function by standard methods. Results. OSA was diagnosed in 373 hypertensives (72.15%). Prevalence of subclinical hypothyroidism was significantly higher in OSA hypertensives than in non-OSA ones (15.0% versus 6.9%, ). Serum LnTSH in hypertensives with severe OSA was significantly higher ( versus μIU/mL, ) than in those without OSA. AHI, LSaO2, ODI3, and ODI4 were independently associated with serum TSH for those aged 30–65 years. Dividing subjects into four groups as TSH < 1.0 μIU/mL, 1.0 ≤ THS ≤ 1.9 μIU/mL, 1.91 ≤ TSH < 4.5 μIU/mL, and TSH ≥ 4.5 μIU/mL, only 26.3% of OSA subjects exhibited TSH between 1.0 and 1.9 μIU/mL, significantly less than non-OSA subjects (26.3% versus 38.2%, ). DBP and serum LDL-c elevated with TSH increasing and were only significantly higher in TSH ≥ 4.5 μIU/mL group than in 1.0 ≤ TSH ≤ 1.9 μIU/mL group ( versus  mmHg; ; versus  mmol/L, ). Conclusion. OSA might be a risk factor for increased TSH even within reference range in hypertensive population.