Review Article
How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin
Table 3
Effects of myo-inositol + melatonin supplementation during ART.
| Authors | Species | Myo-inositol + melatonin in vitro/in vivo | Patients number (tot) | Intervention/control number | Technique | Significant outcomes () |
| Pacchiarotti et al. 2016 [73] | Human | Orally administered MI (4 g/day) + FA (400 mcg/day) + M (3 g/day) versus MI (4 g/day) + FA (400 mcg/day) versus FA (400 mcg/day) | 526 | 165/166/195 | ICSI IVF-ET | (i) Increased mature oocytes (ii) Increased embryos grade 1 (iii) Reduced days of FSH stimulation (iv) Reduced E2 level before hCG |
| Unfer et al. 2011 [75] | Human | Orally administered MI (4 g/day) + FA (400 mcg/day) + M (3 g/day) versus previous failed IVF (themselves) | 46 | 46/46 | IVF-ET | (i) Increased mature oocytes (MII) (ii) Increased embryos grade 1 (iii) Reduced days and UI of FSH stimulation |
| Rizzo et al. 2010 [74] | Human | Orally administered MI (4 g/day) + FA (400 mcg/day) + M (3 g/day) versus MI (4 g/day) + FA (400 mcg/day) | 65 | 32/33 | | (i) Increased mature oocytes (MII) (ii) Increased embryos grade 1-2 |
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MI: myo-inositol; FA: folic acid; M: melatonin; IVF: in vitro fertilization; ET: embryo transfer; ICSI: intracytoplasmic sperm injection; FSH: follicle stimulating hormone; hCG: human chorionic gonadotropin; UI: uterine insemination.
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