Research Article
GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis
Table 2
Genotype distributions of GC rs17467825, rs4588, and rs7041 polymorphisms in the inheritance models.
| | Model | Genotypes | Group HP (%) | Group AgP (%) | Adjusted OR (95% CI) | Adjusted | AIC | BIC |
| | rs17467825 | | | | | | | | | Codominant | A/A | 62 (48.4%) | 170 (46.8%) | 1 | 0.040 | 564.8 | 581.6 | | A/G | 43 (33.6%) | 156 (43%) | 1.33 (0.85–2.08) | | G/G | 23 (18%) | 37 (10.2%) | 0.59 (0.33–1.08) | | Dominant | A/A | 62 (48.4%) | 170 (46.8%) | 1 | 0.730 | 569.1 | 581.7 | | A/G-G/G | 66 (51.6%) | 193 (53.2%) | 1.07 (0.72–1.61) | | Recessive | A/A-A/G | 105 (82%) | 326 (89.8%) | 1 | 0.028 | 564.4 | 577 | | G/G | 23 (18%) | 37 (10.2%) | 0.52 (0.30–0.92) | | Overdominant | A/A-G/G | 85 (66.4%) | 207 (57%) | 1 | 0.059 | 565.7 | 578.3 | | A/G | 43 (33.6%) | 156 (43%) | 1.49 (0.98–2.28) | | Log-additive | — | — | — | 0.88 (0.66–1.18) | 0.410 | 568.6 | 581.1 |
| | rs4588 | | | | | Codominant | C/C | 65 (49.2%) | 168 (45.6%) | 1.00 | 0.190 | 581.9 | 598.7 | | C/A | 48 (36.4%) | 163 (44.3%) | 1.32 (0.86–2.03) | | A/A | 19 (14.4%) | 37 (10.1%) | 0.76 (0.40–1.41) | | Dominant | C/C | 65 (49.2%) | 168 (45.6%) | 1.00 | 0.470 | 582.7 | 595.3 | | C/A-A/A | 67 (50.8%) | 200 (54.4%) | 1.16 (0.78–1.73) | | Recessive | C/C-C/A | 113 (85.6%) | 331 (90%) | 1.00 | 0.190 | 581.4 | 594.1 | | A/A | 19 (14.4%) | 37 (10.1%) | 0.67 (0.37–1.20) | | Overdominant | C/C-A/A | 84 (63.6%) | 205 (55.7%) | 1.00 | 0.110 | 580.6 | 593.3 | | C/A | 48 (36.4%) | 163 (44.3%) | 1.39 (0.93–2.10) | | Log-additive | — | — | — | 0.99 (0.73–1.32) | 0.920 | 583.2 | 595.8 |
| | rs7041 | | | Codominant | T/T | 68 (51.9%) | 190 (52%) | 1.00 | 0.970 | 580.6 | 597.5 | | G/T | 54 (41.2%) | 152 (41.6%) | 1.01 (0.66–1.53) | | G/G | 9 (6.9%) | 23 (6.3%) | 0.92 (0.40–2.08) | | Dominant | T/T | 68 (51.9%) | 190 (52%) | 1.00 | 0.980 | 578.7 | 591.3 | | G/T-G/G | 63 (48.1%) | 175 (48%) | 0.99 (0.67–1.48) | | Recessive | T/T-G/T | 122 (93.1%) | 342 (93.7%) | 1.00 | 0.820 | 578.6 | 591.3 | | G/G | 9 (6.9%) | 23 (6.3%) | 0.91 (0.41–2.03) | | Overdominant | T/T-G/G | 77 (58.8%) | 213 (58.4%) | 1.00 | 0.930 | 578.7 | 591.3 | | G/T | 54 (41.2%) | 152 (41.6%) | 1.02 (0.68–1.53) | | Log-additive | — | — | — | 0.98 (0.71–1.36) | 0.910 | 578.7 | 591.3 |
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AgP: aggressive periodontitis; HP: healthy participant; OR: odds ratio; 95% CI: 95% confidence interval; AIC: Akaike’s information criterion; BIC: Bayesian information criterion; HWE: Hardy Weinberg equilibrium; adjusted : adjusted by age and gender; : statistical significance.
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