The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas

Figure 1

Phosphorylation of AKT, ERK1/2, and mTOR in PPGL tissues. (a) Phosphorylation of AKT, ERK1/2, and mTOR in 6 PPGLs used in in vitro experiments. (b) Phosphorylation of AKT, ERK1/2, and mTOR in 9 PPGLs from patients with different gene mutations. β-Actin was used as a loading control. N: PPGL without gene mutation of SDHB, SDHC, SDHD, VHL, and RET; B: PPGL with SDHB mutation; D: PPGL with SDHD mutation; V: PPGL with VHL mutation; R: PPGL with RET mutation.

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