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International Journal of Endocrinology
Volume 2016 (2016), Article ID 5308347, 5 pages
http://dx.doi.org/10.1155/2016/5308347
Research Article

The Improvement of Hyperglycemia after RYGB Surgery in Diabetic Rats Is Related to Elevated Hypothalamus GLP-1 Receptor Expression

Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Received 13 February 2016; Revised 28 April 2016; Accepted 19 July 2016

Academic Editor: Marco Bugliani

Copyright © 2016 Jazyra Zynat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Stoll, J. C. Silva, L. C. Von Bahten, G. Gugelmin, A. B. Vedan, and B. V. de Souza, “Short-term effect of gastric bypass in obese diabetic patients,” Revista do Colegio Brasileiro de Cirurgioes, vol. 40, no. 1, pp. 11–15, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Yan, L. Tang, T. Chen et al., “Defining and predicting complete remission of type 2 diabetes: a short-term efficacy study of open gastric bypass,” Obesity Facts, vol. 6, no. 2, pp. 176–184, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Rubino, M. Gagner, P. Gentileschi et al., “The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism,” Annals of Surgery, vol. 240, no. 2, pp. 236–242, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. D. E. Cummings, J. Overduin, and K. E. Foster-Schubert, “Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution,” The Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 6, pp. 2608–2615, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. J. J. Holst, “The physiology of glucagon-like peptide 1,” Physiological Reviews, vol. 87, no. 4, pp. 1409–1439, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. L. L. Baggio and D. J. Drucker, “Biology of incretins: GLP-1 and GIP,” Gastroenterology, vol. 132, no. 6, pp. 2131–2157, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. Z. Li, H.-Y. Zhang, L.-X. Lv et al., “Roux-en-Y gastric bypass promotes expression of PDX-1 and regeneration of β-cells in Goto-Kakizaki rats,” World Journal of Gastroenterology, vol. 16, no. 18, pp. 2244–2251, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. B. B. Rice, W. Zhang, S. Bai, P. B. Siegel, M. A. Cline, and E. R. Gilbert, “Insulin-induced hypoglycemia associations with gene expression changes in liver and hypothalamus of chickens from lines selected for low or high body weight,” General and Comparative Endocrinology, vol. 208, pp. 1–4, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. P. R. Schauer, B. Burguera, S. Ikramuddin et al., “Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus,” Annals of Surgery, vol. 238, no. 4, pp. 467–484, 2003. View at Google Scholar
  10. W. J. Pories, M. S. Swanson, K. G. MacDonald et al., “Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus,” Annals of Surgery, vol. 222, no. 3, pp. 339–352, 1995. View at Publisher · View at Google Scholar · View at Scopus
  11. M. E. Doyle and J. M. Egan, “Glucagon-like peptide-1,” Recent Progress in Hormone Research, vol. 56, pp. 377–399, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. G. N. Mallory, A. M. C. Macgregor, and C. S. W. Rand, “The influence of dumping on weight loss after gastric restrictive surgery for morbid obesity,” Obesity Surgery, vol. 6, no. 6, pp. 474–478, 1996. View at Publisher · View at Google Scholar · View at Scopus
  13. Consensus Development Conference Panel, “Gastrointestinal surgery for severe obesity,” Annals of Internal Medicine, vol. 115, no. 12, pp. 956–961, 1991. View at Publisher · View at Google Scholar
  14. C. F. Deacon, M. A. Nauck, M. Toft-Nielsen, L. Pridal, B. Willms, and J. J. Holst, “Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects,” Diabetes, vol. 44, no. 9, pp. 1126–1131, 1995. View at Publisher · View at Google Scholar · View at Scopus
  15. D. J. Drucker and M. A. Nauck, “The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes,” The Lancet, vol. 368, no. 9548, pp. 1696–1705, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Liu, Y. Zhou, Y. Wang, D. Geng, and J. Liu, “Roux-en-Y gastric bypass-induced improvement of glucose tolerance and insulin resistance in type 2 diabetic rats are mediated by glucagon-like peptide-1,” Obesity Surgery, vol. 21, no. 9, pp. 1424–1431, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Broide, O. Bloch, G. Ben-Yehudah, D. Cantrell, H. Shirin, and M. J. Rapoport, “Reduced GLP-1R expression in gastric glands of patients with type 2 diabetes mellitus,” Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 9, pp. E1691–E1695, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. J. J. Holst and C. F. Deacon, “Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes,” Diabetes, vol. 47, no. 11, pp. 1663–1670, 1998. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Mentlein, “Dipeptidyl-peptidase IV (CD26)—role in the inactivation of regulatory peptides,” Regulatory Peptides, vol. 85, no. 1, pp. 9–24, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. M. L. Alam, B. J. Van der Schueren, B. Ahren et al., “Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase-4 activity in obese patients with type 2 diabetes,” Diabetes, Obesity & Metabolism, vol. 13, no. 4, pp. 378–381, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Laferrère, S. Heshka, K. Wang et al., “Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes,” Diabetes Care, vol. 30, no. 7, pp. 1709–1716, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Mannucci, L. Pala, S. Ciani et al., “Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus,” Diabetologia, vol. 48, no. 6, pp. 1168–1172, 2005. View at Publisher · View at Google Scholar · View at Scopus