Research Article
Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid Disease
Table 2
Sonographic correlations of SMK/NMK concentrations.
| Sonographic features | SMK | NMK |
| Nodule volume | | | <10 mL | 0.60 (0.30–4.97) | 0.52 (0.37–1.73) | 10–20 mL | 0.63 (0.33–4.13) | 0.57 (0.35–1.50) | >20 mL | 0.63 (0.33–2.47) | 0.55 (0.35–0.97) | | 0.809 | 0.658 | Nodular echogenicity | | | Hypoechoic | 0.90 (0.47–4.97) | 0.59 (0.35–1.73) | Hyperechoic | 0.55 (0.40–0.93) | 0.55 (0.40–0.68) | Isoechoic | 0.53 (0.30–1.47) | 0.48 (0.35–0.80) | | <0.001 | 0.003 | Calcification | | | Microcalcification | 1.20 (0.60–4.13) | 0.60 (0.43–1.50) | Macrocalcification | 0.63 (0.37–1.10) | 0.56 (0.35–0.65) | No calcification | 0.57 (0.30–4.97) | 0.52 (0.35–1.73) | | 0.001 | 0.308 | Border | | | Regular | 0.59 (0.30–4.97) | 0.49 (0.35–1.73) | Irregular | 0.90 (0.37–2.77) | 0.60 (0.40–1.45) | | 0.015 | 0.001 | Halo | | | Present | 0.57 (0.30–4.97) | 0.50 (0.35–1.73) | Absent | 0.70 (0.37–4.13) | 0.58 (0.35–1.50) | | 0.003 | 0.019 | Nodule structure | | | Heterogeneous | 0.67 (0.30–4.13) | 0.57 (0.35–1.57) | Homogeneous | 0.53 (0.40–4.97) | 0.48 (0.38–1.73) | | 0.023 | 0.031 | Number of nodules | | | Solitary | 0.70 (0.47–2.77) | 0.57 (0.38–1.45) | Multiple | 0.60 (0.30–4.97) | 0.53 (0.35–1.73) | | 0.198 | 0.356 |
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(Hint: : statistically significant.)
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