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International Journal of Endocrinology
Volume 2016, Article ID 6349134, 7 pages
http://dx.doi.org/10.1155/2016/6349134
Research Article

Adipokines and Insulin Resistance in Young Adult Survivors of Childhood Cancer

1Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland
2Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, 15-274 Bialystok, Poland
3Student’s Scientific Society by the Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland

Received 5 January 2016; Accepted 29 March 2016

Academic Editor: Michael Horowitz

Copyright © 2016 Eryk Latoch et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We examined the association between adipokines (leptin, adiponectin, and resistin), radiotherapy, measurement of body fat, and insulin resistance among young adult survivors of childhood cancer (CCS). Materials and Methods. Seventy-six survivors were included (mean age years). Insulin resistance (IR) was calculated using the homeostasis model assessment (HOMA-IR). The serum levels of adipokines were assayed by immunoassays. Fat mass was evaluated by DXA. Results. Mean adiponectin level and mean body FAT were higher in the examined females than in males ( ng/mL versus  ng/mL, ; % versus %, ). Among CCS, one of 75 patients met the criteria of insulin resistance, and in 14 patients there was impaired fasting glucose. The multiple regression model for females showed that leptin/adiponectin ratio (LA ratio) significantly affected HOMA-IR (increase of 0.024 per each unit of LA ratio; ). Radiotherapy had no effect on serum adipokines and IR. Conclusion. The observed results support the hypothesis that adiponectin might be associated with insulin resistance and it can not be ruled out that changes in the mean level of adiponectin per FAT mass or leptin/adiponectin ratio may precede the occurrence of insulin resistance in the future.