Research Article
Pituitary Morphology and Function in 43 Children with Central Diabetes Insipidus
Table 1
Baseline data of all patients with CDI.
| | | | Total | TPS− | TPS+ | |
| | Subjects, | | 43 | 16 | 27 | — |
| | Male/female, | | 23/20 | 12/4 | 11/16 | — | | Age at diagnosis, y | | 7.47 ± 0.49 | 6.58 ± 0.67 | 8.01 ± 0.66 | 0.16 | | Interval, months | | 22.29 ± 3.67 | 18.86 ± 5.99 | 24.32 ± 4.69 | 0.48 |
| | Short stature, | | 17 (39.5%) | 5 (31.3%) | 12 (44.4%) | 0.39 | | Height SDS | | –3.23 ± 0.24 | –3.48 ± 0.45 | –0.13 ± 0.29 | — | | BMI, kg/m2 | | 16.12 ± 0.29 | 15.98 ± 0.42 | 16.20 ± 0.39 | 0.7 | | Urine 24 h, mL/kg | | 202.7 ± 9.83 | 188.6 ± 12.99 | 211.0 ± 13.56 | 0.27 |
| | APD | | 23 (53.5%) | 6 (37.5%) | 17 (63%) | 0.11 | | | IGHD | 15 | 6 (37.5%) | 9 (33.3%) | 0.36 | | | MPHD | 8 | 0 | 8 (29.6%) | 0.02 |
| | GHD +1 | | 5 | 0 | 5 | — | | GHD +2 | | 1 | 0 | 1 | — | | GHD +3 | | 2 | 0 | 2 | — |
| | Pituitary bright spot | | Absent (100%) | Absent (100%) | Absent (100%) | — |
| | AP | Normal | 26 (60.5%) | 12 (75%) | 14 (51.9%) | 0.13 | | <Normal | 11 | 4 (25%) | 7 (25.9%) | 0.95 | | Not visible | 6 | 0 | 6 (22.2%) | 0.04 |
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AP: anterior pituitary; APD: anterior pituitary deficiency; GHD: growth hormone deficiency; IGHD: isolate growth hormone deficiency.
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