Pituitary Morphology and Function in 43 Children with Central Diabetes Insipidus

Table 4

Features of CDI patients.

Patient	Cause of CDI	Age, y	Gender	PSD	AP, mm	Signs and symptoms		PHD
1	Germinoma	9.2	F	17	I	Polyuria, polydipsia, short stature, and anorexia	Trial diagnostic radiation	GH + TSH
2	Germinoma	2.7	F	6.5	<N	Polyuria, polydipsia, and short stature	Trial diagnostic chemotherapy	GH + TSH
3	Germinoma	4.9	F	6.7	<N	Polyuria, polydipsia, short stature, and vomit	Plasma β-HCG	GH + TSH + ACTH, PRL
4	Germinoma	7.6	F	5.5	<N	Polyuria, polydipsia, short stature, and anorexia	Plasma β-HCG	GH + TSH
5	Germinoma	9	M	6.7	I	Short stature, polyuria, and polydipsia	Trial diagnostic radiation	GH
6	Craniopharyngioma	11.5	F	I	I	Short stature and headache	Histological examination after surgery	GH + TSH + ACTH + GnRH
7	Craniopharyngioma	7.9	M	I	I	Short stature and headache	Histological examination after surgery	GH + TSH + ACTH + GnRH, PRL
8	Craniopharyngioma	3	M	I	I	Short stature, polyuria, and polydipsia	Histological examination after surgery	GH + TSH
9	Craniopharyngioma	5.9	M	I	I	Short stature, polyuria, polydipsia, and headache	Histological examination after surgery	GH + TSH
10	LCH	10.6	F	5.5	<N	Polyuria and polydipsia	Trial diagnostic chemotherapy	No
11	LCH	3.5	F	3.9	N	Polyuria, polydipsia, short stature, and rash	Skin biopsy	GH
12–27	Idiopathic	<4.5			<N			GH
		To 6.5			<N			GH

Age at diagnosis; N: normal, 1.1–5 y (4.0 ± 0.7 mm), 5.1–10 (4.5 ± 0.6 mm), and 10.1–15 (5.3 ± 0.8 mm) [8]; ; ; ; .
AP: anterior pituitary; GH: growth hormone; I: invisible; N: normal; PHD: pituitary hormone deficiency; PSD: pituitary stalk diameter.