Clinical Study
Vitamin D Supplementation and Hemoglobin Levels in Hypertensive Patients: A Randomized Controlled Trial
Table 1
Baseline characteristics of the study groups.
| | Characteristics | Vitamin D group | Placebo group | P value | | () | () |
| | Females (%) | 46 | 48 | 0.777 | | Age (years) | 60.5 ± 10.9 | 59.7 ± 11.4 | 0.607 | | Anemic subjects1 (%) | 9 | 4 | 0.152 | | BMI (kg/m2) | 30.4 ± 4.4 | 30.4 ± 6.2 | 0.967 | | Active smoker (%) | 19 | 14 | 0.341 | | Previous MI (%) | 8 | 5 | 0.390 | | Previous stroke (%) | 9 | 7 | 0.602 | | Diabetes mellitus (%) | 32 | 41 | 0.186 | | 25OHD (nmol/L) | 54.5 ± 13.6 | 51.0 ± 14.2 | 0.073 | | PTH (pmol/L) | 5.2 (4.2–6.5) | 5.5 (4.2–7.0) | 0.931 | | Phosphate (mg/dL) | 2.9 ± 0.5 | 3.0 ± 0.5 | 0.085 | | Calcium (mmol/L) | 2.37 ± 0.10 | 2.37 ± 0.11 | 0.989 | | Hemoglobin (g/dL) | 14.4 ± 1.3 | 14.4 ± 1.4 | 0.665 | | Hematocrit (%) | 41.1 ± 3.3 | 41.5 ± 3.4 | 0.329 | | Leukocyte counts (109/L) | 5.9 (5.1–7.0) | 6.0 (5.0–7.5) | 0.817 | | Erythrocyte counts (1012/L) | 4.8 ± 0.4 | 4.9 ± 0.4 | 0.237 | | MCV (µm3) | 86.1 ± 4.4 | 85.7 ± 4.0 | 0.457 | | MCH (pg Hb/red blood cell) | 30.1 ± 1.9 | 29.8 ± 1.6 | 0.234 | | MCHC (g/L) | 34.9 ± 1.0 | 34.7 ± 1.1 | 0.207 | | Platelets (109/L) | 239 ± 64 | 232 ± 50 | 0.442 | | MPV (fl) | 10.7 ± 1.0 | 10.7 ± 0.9 | 0.572 | | CRP (mg/L) | 2.3 (1.13–3.8) | 1.4 (0.9–3.4) | 0.044 | | eGFR (mL/min/1.73 m2) | 80.0 ± 17.9 | 77.2 ± 17.9 | 0.272 | | Vitamin D supplement (%) | 5 | 9 | 0.268 | | ACE-inhibitor (%) | 25 | 38 | 0.048 | | AT II blocker (%) | 33 | 31 | 0.762 | | Diuretic (%) | 42 | 48 | 0.394 | | Beta-blocker (%) | 44 | 49 | 0.478 | | Statin (%) | 26 | 32 | 0.350 | | Calcium channel blocker (%) | 27 | 25 | 0.747 |
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1Hemoglobin <12.5 g/dL.
25OHD: 25-hydroxyvitamin D; ACE: angiotensin converting enzyme; AT: angiotensin; BMI: body mass index; CAD: coronary artery disease; CRP: C-reactive protein; eGFR: estimated globular filtration rate; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; MI: myocardial infarction; MPV: mean platelet volume; PTH: parathyroid hormone.
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