Circulating Visfatin in Hypothyroidism Is Associated with Free Thyroid Hormones and Antithyroperoxidase Antibodies
Table 1
Comparison of clinical and laboratory characteristics between the study groups and controls.
Autoimmune hypothyroidism ()
Nonautoimmune hypothyroidism ()
Controls ()
Sex (F—females; M—males)
F 34 M 5
F 37 M 3
F 34 M 5
0.5420
Age [yr] median (IQR)
46 (34.5–54)
41.5 (29.5–48)
43 (36.3–54)
0.1837
BMI [kg/m2] median (IQR)
23.4 (21.65–25.4)
25.4 (21.55–27.15)
23.3 (20.73–26.13)
0.2704
Glucose [mg/dL] mean (SD)
93 (9.7)
90.8 (9.6)
90.0 (8.0)
0.319
Insulin [μU/mL] mean (SD)
7.7 (3.4)
8.14 (3.12)
8.99 (3.2)
0.202
HOMA-IR mean (SD)
1.77 (0.77)
1.82 (0.72)
2.02 (0.82)
0.316
TSH [μU/mL] median (IQR)
57.3 (35.4–100)
94.5 (62.13–100)
1.8 (1.38–2.57)
<0.0001
FT4 [pmol/L] median (IQR)
5.4 (2.16–8.16)
1.84 (1.34–2.67)
15.96 (14.8–17.39)
<0.0001
FT3 [pmol/L] mean (SD)
2.28 (1.4)
0.7 (0.37)
5.15 (0.57)
<0.001
TPOAb [IU/mL] median (IQR)
189 (56.25–574.5)
11 (7–16)
9 (6–12.75)
<0.001
TgAb [IU/mL] median (IQR)
267 (79–504)
17 (13–21)
10 (10–14)
<0.0001
Tg [ng/mL] mean (SD)
—
0.4 (0.34)
—
—
Visfatin [ng/mL] median (IQR)
10.85 (9.52–13.03)
8.97 (7.25–10.3)
9.54 (8.68–11.4)
0.0001
Values followed by the same letter do not differ significantly. TPOAb antithyroperoxidase antibodies; TgAb antithyroglobulin antibodies; Tg thyroglobulin.
