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International Journal of Endocrinology
Volume 2016, Article ID 7621942, 5 pages
http://dx.doi.org/10.1155/2016/7621942
Clinical Study

Treating Woman with Myo-Inositol Vaginal Suppositories Improves Partner’s Sperm Motility and Fertility

1Department of Obstetrics & Gynecology, Santo Spirito Hospital, 00100 Rome, Italy
2IVF Unit, Villa Mafalda Clinic, 00100 Rome, Italy

Received 11 April 2016; Accepted 17 May 2016

Academic Editor: Vittorio Unfer

Copyright © 2016 Mario Montanino Oliva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. R. W. Fisher and K. Hammarberg, “Psychological and social aspects of infertility in men: an overview of the evidence and implications for psychologically informed clinical care and future research,” Asian Journal of Andrology, vol. 14, no. 1, pp. 121–129, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Singh and D. Jaiswal, “Human male infertility: a complex multifactorial phenotype,” Reproductive Sciences, vol. 18, no. 5, pp. 418–425, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. WHO Laboratory Manual for the Examination and Processing of Human Semen, World Health Organization, Geneva, Switzerland, 5th edition, 2010.
  4. P. J. Beauchamp, P. C. Galle, and L. Blasco, “Human sperm velocity and postinsemination cervical mucus test in the evaluation of the infertile couple,” Archives of Andrology, vol. 13, no. 2-3, pp. 107–112, 1984. View at Publisher · View at Google Scholar · View at Scopus
  5. G. S. Kopf and G. L. Gerton, “The mammalian sperm acrosome and the acrosome reaction,” in Elements of Mammalian Fertilization, P. M. Wasserman, Ed., pp. 153–203, CRC Press, Boston, Mass, USA, 1991. View at Google Scholar
  6. H. Breitbart and B. Spungin, “The biochemistry of the acrosome reaction,” Molecular Human Reproduction, vol. 3, no. 3, pp. 195–202, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. R. J. Aitken, “Sperm function tests and fertility,” International Journal of Andrology, vol. 29, no. 1, pp. 69–108, 2006. View at Google Scholar
  8. R. Boni, R. Gualtieri, R. Talevi, and E. Tosti, “Calcium and other ion dynamics during gamete maturation and fertilization,” Theriogenology, vol. 68, supplement 1, pp. S156–S164, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Colone, G. Marelli, V. Unfer, G. Bozzuto, A. Molinari, and A. Stringaro, “Inositol activity in oligoasthenoteratospermia—an in vitro study,” European Review for Medical and Pharmacological Sciences, vol. 14, no. 10, pp. 891–896, 2010. View at Google Scholar · View at Scopus
  10. R. A. Condorelli, S. La Vignera, F. Di Bari, V. Unfer, and A. E. Calogero, “Effects of myoinositol on sperm mitochondrial function in-vitro,” European Review for Medical and Pharmacological Sciences, vol. 15, no. 2, pp. 129–134, 2011. View at Google Scholar · View at Scopus
  11. R. A. Condorelli, S. La Vignera, S. Bellanca, E. Vicari, and A. E. Calogero, “Myoinositol: does it improve sperm mitochondrial function and sperm motility?” Urology, vol. 79, no. 6, pp. 1290–1295, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. A. E. Calogero, G. Gullo, S. La Vignera, R. A. Condorelli, and A. Vaiarelli, “Myoinositol improves sperm parameters and serum reproductive hormones in patients with idiopathic infertility: a prospective double-blind randomized placebo-controlled study,” Andrology, vol. 3, no. 3, pp. 491–495, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. M. G. R. Hull, P. E. Savage, and D. R. Bromham, “Prognostic value of the postcoital test: prospective study based on time-specific conception rates,” British Journal of Obstetrics and Gynaecology, vol. 89, no. 4, pp. 299–305, 1982. View at Publisher · View at Google Scholar · View at Scopus
  14. K. S. Moghissi, “Postcoital test: physiologic basis, technique, and interpretation,” Fertility and Sterility, vol. 27, no. 2, pp. 117–129, 1976. View at Publisher · View at Google Scholar · View at Scopus
  15. M. G. R. Hull, C. M. A. Glazener, N. J. Kelly et al., “Population study of causes, treatment, and outcome of infertility,” The British Medical Journal, vol. 291, no. 6510, pp. 1693–1697, 1985. View at Publisher · View at Google Scholar · View at Scopus
  16. D. S. Irvine, “Epidemiology and aetiology of male infertility,” Human Reproduction, vol. 13, no. 1, pp. 33–44, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. C. L. R. Barratt, S. Mansell, C. Beaton, S. Tardif, and S. K. Oxenham, “Diagnostic tools in male infertility-the question of sperm dysfunction,” Asian Journal of Andrology, vol. 13, no. 1, pp. 53–58, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. J. W. Van Der Steeg, P. Steures, M. J. C. Eijkemans et al., “Role of semen analysis in subfertile couples,” Fertility and Sterility, vol. 95, no. 3, pp. 1013–1019, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Tomlinson, S. Lewis, and D. Morroll, “Sperm quality and its relationship to natural and assisted conception: British Fertility Society Guidelines for practice,” Human Fertility, vol. 16, no. 3, pp. 175–193, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Marchetti, G. Obert, A. Deffosez, P. Formstecher, and P. Marchetti, “Study of mitochondrial membrane potential, reactive oxygen species, DNA fragmentation and cell viability by flow cytometry in human sperm,” Human Reproduction, vol. 17, no. 5, pp. 1257–1265, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. X. Wang, R. K. Sharma, A. Gupta et al., “Alterations in mitochondria membrane potential and oxidative stress in infertile men: a prospective observational study,” Fertility and Sterility, vol. 80, no. 2, pp. 844–850, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Ren, B. Navarro, G. Perez et al., “A sperm ion channel required for sperm motility and male fertility,” Nature, vol. 413, no. 6856, pp. 603–609, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. A. E. Carlson, R. E. Westenbroek, T. Quill et al., “CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 25, pp. 14864–14868, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. T. A. Quill, S. A. Sugden, K. L. Rossi, L. K. Doolittle, R. E. Hammer, and D. L. Garbers, “Hyperactivated sperm motility driven by CatSper2 is required for fertilization,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 25, pp. 14869–14874, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Ho, C. A. Wolff, and S. S. Suarez, “CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir,” Reproduction, Fertility and Development, vol. 21, no. 2, pp. 345–350, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Bahat and M. Eisenbach, “Human sperm thermotaxis is mediated by phospholipase C and inositol trisphosphate receptor Ca2+ channel,” Biology of Reproduction, vol. 82, no. 3, pp. 606–616, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. E. Dragileva, S. Rubinstein, and H. Breitbart, “Intracellular Ca2+-Mg2+-ATPase regulates calcium influx and acrosomal exocytosis in bull and ram spermatozoa,” Biology of Reproduction, vol. 61, no. 5, pp. 1226–1234, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. H.-C. Ho and S. S. Suarez, “Characterization of the intracellular calcium store at the base of the sperm flagellum that regulates hyperactivated motility,” Biology of Reproduction, vol. 68, no. 5, pp. 1590–1596, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Lambert, J. A. Talbot, R. Mitchell, and W. R. Robertson, “Inhibition of protein kinase C by staurosporine increases estrogen secretion by rat Sertoli cells,” Acta Endocrinologica, vol. 125, no. 3, pp. 286–290, 1991. View at Google Scholar · View at Scopus
  30. S. B. Meroni, M. F. Riera, E. H. Pellizzari, and S. B. Cigorraga, “Regulation of rat sertoli cell function by FSH: possible role of phosphatidylinositol 3-kinase/protein kinase B pathway,” The Journal of Endocrinology, vol. 174, no. 2, pp. 195–204, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Nishizuka, “Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C,” Science, vol. 258, no. 5082, pp. 607–614, 1992. View at Publisher · View at Google Scholar · View at Scopus
  32. A. J. Sobrero and J. Macleod, “The immediate postcoital test,” Fertility and sterility, vol. 13, pp. 184–189, 1962. View at Publisher · View at Google Scholar · View at Scopus
  33. C. S. Griffith and D. A. Grimes, “The validity of the postcoital test,” American Journal of Obstetrics & Gynecology, vol. 162, no. 3, pp. 615–620, 1990. View at Publisher · View at Google Scholar · View at Scopus
  34. J. M. Eimers, E. R. te Velde, R. Gerritse, R. J. van Kooy, J. Kremer, and J. D. F. Habbema, “The validity of the postcoital test for estimating the probability of conceiving,” American Journal of Obstetrics and Gynecology, vol. 171, no. 1, pp. 65–70, 1994. View at Publisher · View at Google Scholar · View at Scopus
  35. S. G. Oei, F. M. Helmerhorst, and M. J. Keirse, “Routine postcoital testing is unnecessary,” Human Reproduction, vol. 16, no. 5, pp. 1051–1053, 2001. View at Google Scholar
  36. S. G. Oei, “The postcoital test: a controversial investigation,” European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 77, no. 2, pp. 123–124, 1998. View at Publisher · View at Google Scholar · View at Scopus
  37. J. W. van der Steeg, P. Steures, M. J. C. Eijkemans et al., “Should the postcoital test (PCT) be part of the routine fertility workup?” Human Reproduction, vol. 19, no. 6, pp. 1373–1379, 2004. View at Publisher · View at Google Scholar
  38. C. M. A. Glazener, W. C. L. Ford, and M. G. R. Hull, “The prognostic power of the post-coital test for natural conception depends on duration of infertility,” Human Reproduction, vol. 15, no. 9, pp. 1953–1957, 2000. View at Publisher · View at Google Scholar · View at Scopus