Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia

Figure 1

Aerobic glycolysis in the cytosol of cells produces pyruvate that enters the mitochondria where it is oxidized to acetyl-CoA by the pyruvate dehydrogenase complex (PDC). Inositol phosphoglycans (IPG) regulate the activation of PDC and, in its myo-inositol form (IPG-A), promote also lipogenesis in the cytosol. Zinc and manganese hold a key role in this system being involved in most steps as shown.