Human Adrenocortical Remodeling Leading to Aldosterone-Producing Cell Cluster Generation
Table 1
Patient characteristics, AA/WAA, and NOA/WAA.
Case #
Section #
Age
Sex
Cause of death
AA/WAA (%)
NOA/WAA (APCCs/mm2)
1
A021
0.75
F
Postliver transplantation
2
A022
1
M
Heterotaxy syndrome
3
A023
1
F
Brain tumor
4
A024
1.8
M
Postliver transplantation
5
A025
2
M
Acute lung dysfunction
6
A026
3
F
Pulmonary dysfunction
7
A027
10
M
Encephalopathy due to Reye’s syndrome
8
A028
11
F
Malignant peripheral nerve sheath tumors
10
A030
18
M
Hemophagocytic syndrome
12
A032
19
F
Postliver transplantation
14
A034
22
F
Malignant intrapelvic tumor
16
A036
24
F
Pulmonary hypertension
19
A039
28
F
Pulmonary alveolar hemorrhage
21
A042
29
M
Sepsis due to acute myelocytic leukemia
22
A043
29
F
Subarachnoid hemorrhage
23
A044, A045
33
M
Sepsis
24
A046
33
M
Acute heart failure
25
A047
34
M
Aorta stenosis
27
A049
38
F
Sepsis
28
A050
38
M
Liver cirrhosis
29
A051
39
M
Myelodysplastic syndrome
30
A052
40
F
Gastric cancer
31
A053
40
F
Pulmonitis due to systemic lupus erythematosus
32
A054, A055
41
F
Ovarian carcinoma
36
A059
44
F
Renal cell carcinoma
37
A060
45
M
Heart failure
38
A061
45
M
Lung cancer
40
A063
45
M
Hepatic failure due to liver cancer
42
A065
45
M
Heart failure
43
A066
47
M
Bronchiectasis
44
A067
48
F
Pulmonary hypertension
47
A071
50
M
Heart failure
48
A072
37
M
Acute pancreatitis
F: female; M: male; AA/WAA: percentage of APCC areas over the whole adrenal area; NOA: number of APCCs/mm2. Each value of AA/WAA and NOA by individual examiners and the characteristics of cases not used in statistical analyses are shown in Supplementary Figure .
