Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up

Table 2

Radiological and immunohistochemical characterization of tumors on diagnosis.

Radiological aspects	Total (%)
	Tumor size (mm)
Parasellar invasion	42 (84)
Infrasellar invasion	40 (80)
Suprasellar extension	49 (98)
3rd ventricle extension	32 (64)
Immunohistochemistry	Total (%)
Hormonal expression
GH	14 (28)
PRL	8 (16)
ACTH	3 (6)
LH/FSH	7 (14)
Null cell	18 (36)
p53
≥3+	29 (60)
Ki-67
≥2+	16 (33)
c-erbB2
≥2+	31 (67)
Clinicopathological classification	Total (%)
Grades
1A	2 (4)
1B	1 (2)
2A	21 (42)
2B	26 (52)

Values expressed as mean ± SD or frequency (%).