Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up
Table 3
Evaluation of p53, Ki-67, and c-erbB2 tumor proliferation markers based on clinical and radiological parameters.
p53
Ki-67
c-erbB2
<3+
≥3+
<2+
≥2+
<2+
≥2+
Age (years)†
0.021
<0.001
0.955
Diameter (mm)†
0.062
0.009
0.937
Invasion
Parasellar
0.235
0.701
0.703
No
5 (26)
3 (10)
6 (19)
2 (13)
2 (13)
6 (19)
Yes
14 (74)
26 (90)
26 (81)
14 (87)
13 (87)
25 (81)
Infrasellar
0.451
0.238
0.242
No
5 (26)
4 (14)
8 (25)
1 (6)
1 (7)
7 (23)
Yes
14 (74)
25 (86)
24 (75)
15 (94)
14 (93)
24 (77)
Extension
Suprasellar
0.395
1.000
1.000
No
1 (5)
0 (0)
1 (3)
0 (0)
0 (0)
1 (3)
Yes
18 (95)
29 (100)
31 (97)
16 (100)
15 (100)
30 (97)
3rd ventricle
0.013
0.087
0.421
No
11 (58)
6 (21)
14 (44)
3 (19)
4 (36)
12 (39)
Yes
8 (42)
23 (79)
18 (56)
13 (81)
11 (64)
19 (61)
value computed using Student’s -, Pearson’s chi-square, or Fisher’s exact test. Mean ± standard deviation or frequency (%).
