Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up
Table 5
Immunohistochemical profile, tumor classification, and therapeutic intervention.
Therapeutic interventions
value
Only surgery (%)
Surgery and medical treatment (%)
Surgery and radiotherapy (%)
Surgery, medical treatment, and radiotherapy (%)
Patients ()
11 (22)
20 (40)
11 (22)
8 (16)
Immunohistochemistry
Hormone expression
0.0186
GH ()
1 (7)
9 (64)
0 (0.00)
4 (29)
PRL ()
1 (13)
6 (74)
0 (0.00)
1 (13)
ACTH ()
1 (33)
0 (0)
1 (33)
1 (33)
LH/FSH ()
2 (29)
2 (29)
3 (42)
0 (0)
Null cell ()
6 (33)
3 (17)
7 (39)
2 (11)
Tumor markers
p53
0.1527
<3+
4 (21)
4 (21)
7 (37)
4 (21)
≥3+
7 (24)
14 (48)
4 (14)
4 (14)
Ki-67
0.0110
<2+
10 (31)
8 (25)
10 (31)
5 (13)
≥2+
1 (6)
10 (63)
1 (6)
4 (25)
c-erbB2
0.3018
<2+
4 (27)
8 (53)
2 (13)
1 (7)
≥2+
7 (23)
9 (29)
9 (29)
6 (19)
Clinicopathological classification
0.6858
1A
1 (50)
0 (0)
0 (0)
1 (50)
1B
0 (0)
0 (0)
1 (100)
0 (0)
2A
4 (19)
9 (43)
5 (24)
3 (14)
2B
6 (23)
11 (43)
5 (19)
4 (15)
Values expressed as frequency (%) and [Pearson residual]. value computed using Pearson’s chi-square test.
