Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up
Table 7
Immunohistochemical profile, classification, and tumor evolution classes.
Clinical outcomes
value
Regrowth/recurrence (%)
Stability (%)
Reduction/cure (%)
Immunohistochemistry
Hormone expression
0.2193
GH
3 (18)
2 (15)
9 (45)
PRL
3 (18)
1 (8)
4 (20)
ACTH
2 (11)
1 (8)
0 (0)
LH/FSH
3 (18)
1 (8)
3 (15)
Null cell
6 (35)
8 (61)
4 (20)
p53
0.0035
<3+
3 (18)
10 (77)
6 (33)
≥3+
14 (82)
3 (23)
12 (67)
Ki-67
0.2329
<2+
11 (65)
11 (85)
10 (56)
≥2+
6 (35)
2 (15)
8 (44)
c-erbB2
0.7118
<2+
4 (25)
5 (38)
6 (35)
≥2+
12 (75)
8 (62)
11 (65)
Classification
Anatomical
0.5155
Noninvasive
1 (6)
2 (15)
0 (0)
Invasive
16 (94)
11 (85)
20 (100)
Pathological
0.0145
Nonproliferative
4 (24)
10 (77)
9 (45)
Proliferative
13 (76)
3 (23)
11 (55)
Clinicopathological
0.0127
Grades
1A
0 (0)
2 (15)
0 (0)
1B
1 (6)
0 (0)
0 (0)
2A
4 (24)
8 (62)
9 (45)
2B
12 (70)
3 (23)
11 (55)
Pearson’s chi-square test; values expressed as frequency (%) and [Pearson residual] were tested to identify variables that contributed to statistical significance.
