Clinical Study
The Role of Isotretinoin Therapy for Cushing’s Disease: Results of a Prospective Study
Table 2
Comparison of responsive and nonresponsive patients.
| Features | Responsive patients () | Nonresponsive patients () | P value |
| Mean age (years) | 38.5 9.54 | 45.58 7.14 | <0.01 | Mean UFC (mg/day) | 202.33 29.73 | 243.37 40.22 | <0.01 | Mean ACTH (pg/mL) | 54.02 13.95 | 62.23 16.77 | <0.01 | Mean midnight salivary cortisol (ng/dL) | 168.47 7.49 | 229.93 40.31 | <0.01 | Mean retinoic acid dose (mg/day) | 70.0 11.54 | 80.00 0.00 | 0.02 | Rate of visible tumor on MRI (%) | 50 | 50 | 1 | Rate of male patients (%) | 75 | 50 | 0.58 | Rate of female patients (%) | 25 | 50 | 0.58 | Rate of patients with UFC levels 2.5-fold ULN (%) | 100 | 25 | 0.02 |
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