The Role of Isotretinoin Therapy for Cushing’s Disease: Results of a Prospective Study

Table 2

Comparison of responsive and nonresponsive patients.

Features	Responsive patients; ()	Nonresponsive patients ()	P value
Mean age (years)	38.5 9.54	45.58 7.14	<0.01
Mean UFC (mg/day)	202.33 29.73	243.37 40.22	<0.01
Mean ACTH (pg/mL)	54.02 13.95	62.23 16.77	<0.01
Mean midnight salivary cortisol (ng/dL)	168.47 7.49	229.93 40.31	<0.01
Mean retinoic acid dose (mg/day)	70.0 11.54	80.00 0.00	0.02
Rate of visible tumor on MRI (%)	50	50	1
Rate of male patients (%)	75	50	0.58
Rate of female patients (%)	25	50	0.58
Rate of patients with UFC levels 2.5-fold ULN (%)	100	25	0.02