Multidrug-Resistant Tuberculosis and Its Association with Adrenal Insufficiency: Assessment with the Low-Dose ACTH Stimulation Test

Table 2

Serum cortisol responses to the low-dose ACTH stimulation test at baseline and follow-up.

	Total population ()		Primary MDR-TB ()		Secondary MDR-TB ()
	Baseline	Follow-up	Baseline	Follow-up	Baseline	Follow-up
Serum cortisol (nmol/L)
Baseline	464.1 ± 211.2	476.8 ± 306.6	480.1 ± 202.4	467.9 ± 315.6	449.5 ± 222.2	488.7 ± 307.7
30 min	787.2 ± 173.1	912.8 ± 213.8	787.7 ± 179.4	856.6 ± 239.3	786.8 ± 170.8	987.6 ± 152.9
60 min	831.3 ± 192.7	991.8 ± 236.3	854.59 ± 224.9	918.9 ± 265.9	809.9 ± 159.4	1088.9 ± 150.1
Increase in serum cortisol (%)
0′–30 min	102.7 ± 99.3	160.3 ± 174.9	99.5 ± 120.2	145 ± 163.5	105.7 ± 77.8	180.7 ± 194.5
0′–60 min	116.3 ± 115.1	182.8 ± 188.3	115 ± 135.1	168.1 ± 197.4	117.5 ± 96.1	202.3 ± 182.1
Normal cortisol responders (/%)
500 nmol/L cutoff point	46, (95.8)	33, (100)	22 (95.6)	19, (100)	24, (96)	14 (100)
550 nmol/L cutoff point	44, (91.7)	33, (100)	22 (95.6)	19, (100)	22, (88)	14 (100)

MDR-TB: multidrug-resistant tuberculosis.