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International Journal of Endocrinology
Volume 2017, Article ID 1365209, 9 pages
https://doi.org/10.1155/2017/1365209
Research Article

Combination Therapy with a Sodium-Glucose Cotransporter 2 Inhibitor and a Dipeptidyl Peptidase-4 Inhibitor Additively Suppresses Macrophage Foam Cell Formation and Atherosclerosis in Diabetic Mice

1Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Tokyo, Japan
2Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
3Laboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

Correspondence should be addressed to Tsutomu Hirano; pj.ca.u-awohs.dem@onarih

Received 8 December 2016; Accepted 12 February 2017; Published 19 March 2017

Academic Editor: Maria L. Dufau

Copyright © 2017 Michishige Terasaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Z. Shah, T. Kampfrath, J. A. Deiuliis et al., “Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis,” Circulation, vol. 124, no. 21, pp. 2338–2349, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. N. N. Ta, C. A. Schuyler, Y. Li, M. F. Lopes-Virella, and Y. Huang, “DPP-4 (CD26) inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice,” Journal of Cardiovascular Pharmacology, vol. 58, no. 2, pp. 157–166, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Vittone, A. Liberman, D. Vasic et al., “Sitagliptin reduces plaque macrophage content and stabilises arteriosclerotic lesions in Apoe (-/-) mice,” Diabetologia, vol. 55, no. 8, pp. 2267–2275, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Ervinna, T. Mita, E. Yasunari et al., “Anagliptin, a DPP-4 inhibitor, suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction and attenuates atherosclerosis in male apo E-deficient mice,” Endocrinology, vol. 154, no. 3, pp. 1260–1270, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Terasaki, M. Nagashima, T. Watanabe et al., “Effects of PKF275-055, a dipeptidyl peptidase-4 inhibitor, on the development of atherosclerotic lesions in apolipoprotein E-null mice,” Metabolism, vol. 61, no. 7, pp. 974–977, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Terasaki, M. Nagashima, K. Nohtomi et al., “Preventive effect of dipeptidyl peptidase-4 inhibitor on atherosclerosis is mainly attributable to incretin’s actions in nondiabetic and diabetic apolipoprotein E-null mice,” PLoS One, vol. 8, no. 8, article e70933, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Terasaki, M. Hiromura, Y. Mori et al., “Amelioration of hyperglycemia with a sodium-glucose cotransporter 2 inhibitor prevents macrophage-driven atherosclerosis through macrophage foam cell formation suppression in type 1 and type 2 diabetic mice,” PLoS One, vol. 10, no. 11, article e0143396, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Allahverdian, P. S. Pannu, and G. A. Francis, “Contribution of monocyte-derived macrophages and smooth muscle cells to arterial foam cell formation,” Cardiovascular Research, vol. 95, no. 2, pp. 165–172, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Nagashima, T. Watanabe, M. Terasaki et al., “Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice,” Diabetologia, vol. 54, no. 10, pp. 2649–2659, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Kohashi, M. Hiromura, Y. Mori et al., “A dipeptidyl peptidase-4 inhibitor but not incretins suppresses abdominal aortic aneurysms in angiotensin II-infused apolipoprotein E-null mice,” Journal of Atherosclerosis and Thrombosis, vol. 23, no. 4, pp. 441–454, 2016. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Li, T. Sawamura, and G. Renier, “Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation,” Circulation Research, vol. 94, no. 7, pp. 892–901, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Griffin, A. Re, N. Hamel et al., “A link between diabetes and atherosclerosis: glucose regulates expression of CD36 at the level of translation,” Nature Medicine, vol. 7, no. 7, pp. 840–846, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Fukuhara-Takaki, M. Sakai, Y. Sakamoto, M. Takeya, and S. Horiuchi, “Expression of class a scavenger receptor is enhanced by high glucose in vitro and under diabetic conditions in vivo: one mechanism for an increased rate of atherosclerosis in diabetes,” The Journal of Biological Chemistry, vol. 280, no. 5, pp. 3355–3364, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Lu, K. Yao, D. Huang et al., “High glucose induces upregulation of scavenger receptors and promotes maturation of dendritic cells,” Cardiovascular Diabetology, vol. 12, p. 80, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Dai, X. Wang, Z. Ding, D. Dai, and J. L. Mehta, “DPP-4 inhibitors repress foam cell formation by inhibiting scavenger receptors through protein kinase C pathway,” Acta Dibetologica, vol. 51, no. 3, pp. 471–478, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. C. Chang, W. H. Sheu, Y. S. Chien, P. C. Tseng, W. J. Lee, and A. N. Chiang, “Hyperglycemia accelerates ATP-binding cassette transporter A1 degradation via an ERK-dependent pathway in macrophages,” Journal of Cellular Biochemistry, vol. 114, no. 6, pp. 1364–1373, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Mauerer, S. Ebert, and T. Langmann, “High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1 in human macrophages,” Experimental & Molecular Medicine, vol. 41, no. 2, pp. 126–132, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Machado-Lima, R. T. Iborra, R. S. Pinto et al., “In type 2 diabetes mellitus glycated albumin alters macrophage gene expression impairing ABCA1-mediated cholesterol efflux,” Journal of Cellular Physiology, vol. 230, no. 6, pp. 1250–1257, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Tashiro, K. Sato, T. Watanabe et al., “A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis,” Peptides, vol. 54, pp. 19–26, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Nishiuchi, K. Murao, H. Imachi, T. Nishiuchi, H. Iwama, and T. Ishida, “Transcriptional factor prolactin regulatory element-binding protein-mediated gene transcription of ABCA1 via 3′,5′-cyclic adenosine-5′-monophosphate,” Atherosclerosis, vol. 212, no. 2, pp. 418–425, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. I. C. Gelissen, L. J. Sharpe, C. Sandoval et al., “Protein kinase A modulates the activity of a major human isoform of ABCG1,” Journal of Lipid Research, vol. 53, no. 10, pp. 2133–2140, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Schulte, G. K. Sukhova, and P. Libby, “Genetically programmed biases in Th1 and Th2 immune responses modulate Atherogenesis,” The American Journal of Pathology, vol. 172, no. 6, pp. 1500–1508, 2008. View at Publisher · View at Google Scholar · View at Scopus