Screening for Cushing Syndrome at the Primary Care Level: What Every General Practitioner Must Know

Table 1

Conditions suggested by the Endocrine Society that may present as pseudo Cushing’s syndrome [2].

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Physiologic hypercortisolism in the absence of Cushing’s syndrome

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May have Cushing’s syndrome features

Pregnancy

Depression

Other psychiatric diseases

Alcohol dependence

Glucocorticoid resistance

Morbid obesity

Uncontrolled diabetes

May not have Cushing’s syndrome features

Physical stress such as hospitalization, surgery, and pain

Malnutrition

Anorexia nervosa

Vigorous chronic exercise

Hypothalamic amenorrhea

CBG excess (serum cortisol increase; not UFC)

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CBG: cortisol-binding globulin; UFC: urinary free cortisol.