International Journal of Endocrinology / 2017 / Article / Fig 1

Research Article

A New Murine Model of Chronic Kidney Disease-Mineral and Bone Disorder

Figure 1

Kidney phenotype of the CKD model. Mice were either fed with HPD for 4 (HPD4, ) or 7 days (HPD7, ) and then followed on SCD until day 84. They were compared with mice on SCD for the complete study period (SCD, ). (a) Kidneys were evaluated for calcium hydroxyapatite crystals and fibrosis by performing alizarin red and sirius red stain, respectively. Representative pictures are provided. (b) On day 84, FITC-inulin clearance to evaluate the glomerular filtration rate (GFR) was performed. The GFR in percentage compared to SCD is provided. (c) Representative GFR curves of SCD and 7-day HPD 7 mice are provided. (d) Serum urea was evaluated in mice on day 84. .

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