Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2017, Article ID 2021903, 11 pages
https://doi.org/10.1155/2017/2021903
Research Article

Regulation of Corticosteroidogenic Genes by MicroRNAs

1Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, UK
2Ninewells Hospital and Medical School, University of Dundee, Dundee, UK

Correspondence should be addressed to Eleanor Davies; ku.ca.wogsalg@seivad.ronaele

Received 29 March 2017; Revised 30 May 2017; Accepted 18 June 2017; Published 9 August 2017

Academic Editor: Carmela Maniero

Copyright © 2017 Stacy Robertson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Arnaldi, A. Angeli, A. B. Atkinson et al., “Diagnosis and complications of Cushing’s syndrome: a consensus statement,” The Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 12, pp. 5593–5602, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Milliez, X. Girerd, P. F. Plouin, J. Blacher, M. E. Safar, and J. J. Mourad, “Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism,” Journal of the American College of Cardiology, vol. 45, no. 8, pp. 1243–1248, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. D. G. Levy, R. Rocha, and J. W. Funder, “Distinguishing the antihypertensive and electrolyte effects of eplerenone,” The Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 6, pp. 2736–2740, 2004. View at Google Scholar
  4. J. M. Connell and E. Davies, “The new biology of aldosterone,” The Journal of Endocrinology, vol. 186, no. 1, pp. 1–20, 2005. View at Google Scholar
  5. J. W. Funder, P. T. Pearce, R. Smith, and A. I. Smith, “Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated,” Science, vol. 242, no. 4878, pp. 583–585, 1988. View at Publisher · View at Google Scholar
  6. C. R. Edwards, P. M. Stewart, D. Burt et al., “Localisation of 11 beta-hydroxysteroid dehydrogenase—tissue specific protector of the mineralocorticoid receptor,” Lancet, vol. 2, no. 8618, pp. 986–989, 1988. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Young, M. Fullerton, R. Dilley, and J. Funder, “Mineralocorticoids, hypertension, and cardiac fibrosis,” The Journal of Clinical Investigation, vol. 93, no. 6, pp. 2578–2583, 1994. View at Google Scholar
  8. S. Robertson, S. M. MacKenzie, S. Alvarez-Madrazo et al., “MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex,” Hypertension, vol. 62, no. 3, pp. 572–578, 2013. View at Google Scholar
  9. C. C. Huang and H. H. Yao, “Inactivation of Dicer1 in steroidogenic factor 1-positive cells reveals tissue-specific requirement for Dicer1 in adrenal, testis, and ovary,” BMC Developmental Biology, vol. 10, p. 66, 2010. View at Google Scholar
  10. D. G. Romero, M. W. Plonczynski, C. A. Carvajal, E. P. Gomez-Sanchez, and C. E. Gomez-Sanchez, “Microribonucleic acid-21 increases aldosterone secretion and proliferation in H295R human adrenocortical cells,” Endocrinology, vol. 149, no. 5, pp. 2477–2483, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Nusrin, S. K. Tong, G. Chaturvedi, R. S. Wu, J. P. Giesy, and R. Y. Kong, “Regulation of CYP11B1 and CYP11B2 steroidogenic genes by hypoxia-inducible miR-10b in H295R cells,” Marine Pollution Bulletin, vol. 85, no. 2, pp. 344–351, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. B. C. Schanen and X. Li, “Transcriptional regulation of mammalian miRNA genes,” Genomics, vol. 97, no. 1, pp. 1–6, 2011. View at Google Scholar
  13. M. Ha and V. N. Kim, “Regulation of microRNA biogenesis,” Nature Reviews. Molecular Cell Biology, vol. 15, no. 8, pp. 509–524, 2014. View at Google Scholar
  14. T. Thum and M. Mayr, “Review focus on the role of microRNA in cardiovascular biology and disease,” Cardiovascular Research, vol. 93, no. 4, pp. 543-544, 2012. View at Google Scholar
  15. J. R. Kemp, H. Unal, R. Desnoyer, H. Yue, A. Bhatnagar, and S. S. Karnik, “Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system,” Journal of Molecular and Cellular Cardiology, vol. 75, pp. 25–39, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. M. D. Jansson and A. H. Lund, “MicroRNA and cancer,” Molecular Oncology, vol. 6, no. 6, pp. 590–610, 2012. View at Google Scholar
  17. P. S. Soon, L. J. Tacon, A. J. Gill et al., “miR-195 and miR-483-5p identified as predictors of poor prognosis in adrenocortical cancer,” Clinical Cancer Research, vol. 15, no. 24, pp. 7684–7692, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. E. I. Bimpaki, D. Iliopoulos, A. Moraitis, and C. A. Stratakis, “MicroRNA signature in massive macronodular adrenocortical disease and implications for adrenocortical tumourigenesis,” Clinical Endocrinology, vol. 72, no. 6, pp. 744–751, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Iliopoulos, E. I. Bimpaki, M. Nesterova, and C. A. Stratakis, “MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling,” Cancer Research, vol. 69, no. 8, pp. 3278–3282, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. Z. Tombol, P. M. Szabó, V. Molnár et al., “Integrative molecular bioinformatics study of human adrenocortical tumors: microRNA, tissue-specific target prediction, and pathway analysis,” Endocrine-Related Cancer, vol. 16, no. 3, pp. 895–906, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. K. J. Schmitz, J. Helwig, S. Bertram et al., “Differential expression of microRNA-675, microRNA-139-3p and microRNA-335 in benign and malignant adrenocortical tumours,” Journal of Clinical Pathology, vol. 64, no. 6, pp. 529–535, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Velazquez-Fernandez, S. Caramuta, D. M. Özata et al., “MicroRNA expression patterns associated with hyperfunctioning and non-hyperfunctioning phenotypes in adrenocortical adenomas,” European Journal of Endocrinology, vol. 170, no. 4, pp. 583–591, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Lenzini, B. Caroccia, A. G. Campos et al., “Lower expression of the TWIK-related acid-sensitive K+channel 2 (TASK-2) gene is a hallmark of aldosterone-producing adenoma causing human primary aldosteronism,” The Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 4, pp. E674–E682, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. W. E. Rainey, I. M. Bird, and J. I. Mason, “The NCI-H295 cell line: a pluripotent model for human adrenocortical studies,” Molecular and Cellular Endocrinology, vol. 100, no. 1-2, pp. 45–50, 1994. View at Google Scholar
  25. M. C. Ingram and R. Fraser, “Plasma corticosteroid profiling: brief opinion of its current status in clinical diagnosis and research,” Expert Review of Endocrinology and Metabolism, vol. 5, no. 2, pp. 181–188, 2010. View at Google Scholar
  26. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2(−delta delta C(T)) method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Google Scholar
  27. Z. Hu, W. J. Shen, Y. Cortez et al., “Hormonal regulation of microRNA expression in steroid producing cells of the ovary, testis and adrenal gland,” PloS One, vol. 8, no. 10, article e78040, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Han, C. A. Staab-Weijnitz, G. Xiong, and E. Maser, “Identification of microRNAs as a potential novel regulatory mechanism in HSD11B1 expression,” The Journal of Steroid Biochemistry and Molecular Biology, vol. 133, pp. 129–139, 2013. View at Google Scholar
  29. M. Rezaei, T. Andrieu, S. Neuenschwander et al., “Regulation of 11beta-hydroxysteroid dehydrogenase type 2 by microRNA,” Hypertension, vol. 64, no. 4, pp. 860–866, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. T. M. Witkos, E. Koscianska, and W. J. Krzyzosiak, “Practical aspects of microRNA target prediction,” Current Molecular Medicine, vol. 11, no. 2, pp. 93–109, 2011. View at Google Scholar
  31. Y. Tay, J. Zhang, A. M. Thomson, B. Lim, and I. Rigoutsos, “MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation,” Nature, vol. 455, no. 7216, pp. 1124–1128, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. J. R. Lytle, T. A. Yario, and J. A. Steitz, “Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 23, pp. 9667–9672, 2007. View at Google Scholar
  33. A. Stark, J. Brennecke, N. Bushati, R. B. Russell, and S. M. Cohen, “Animal microRNAs confer robustness to gene expression and have a significant impact on 3′UTR evolution,” Cell, vol. 123, no. 6, pp. 1133–1146, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. Y. M. Sun, K. Y. Lin, and Y. Q. Chen, “Diverse functions of miR-125 family in different cell contexts,” Journal of Hematology & Oncology, vol. 6, p. 6, 2013. View at Google Scholar
  35. D. Li, P. Yang, Q. Xiong et al., “MicroRNA-125a/b-5p inhibits endothelin-1 expression in vascular endothelial cells,” Journal of Hypertension, vol. 28, no. 8, pp. 1646–1654, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. Z. Xishan, L. Ziying, D. Jing, and L. Gang, “MicroRNA-320a acts as a tumor suppressor by targeting BCR/ABL oncogene in chronic myeloid leukemia,” Scientific Reports, vol. 5, article 12460, 2015. View at Google Scholar
  37. S. Sepramaniam, A. Armugam, K. Y. Lim et al., “MicroRNA 320a functions as a novel endogenous modulator of aquaporins 1 and 4 as well as a potential therapeutic target in cerebral ischemia,” The Journal of Biological Chemistry, vol. 285, no. 38, pp. 29223–29230, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. T. Wang, F. Satoh, R. Morimoto et al., “Gene expression profiles in aldosterone-producing adenomas and adjacent adrenal glands,” European Journal of Endocrinology, vol. 164, no. 4, pp. 613–619, 2011. View at Publisher · View at Google Scholar · View at Scopus