Research Article
Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients
Table 3
Allele frequencies of Toll-like receptor polymorphism in controls and patients with thyroid disease.
| | SNP alleles | Normal | AITD | GD | HD | | 2n = 366 (%) | 2n = 208 (%) | 2n = 120 (%) | 2n = 88 (%) |
| | TLR1 (+742) | C | 235 (64.2) | 126 (60.6) | 74 (61.7) | 52 (59.1) | | rs4833095 | T | 131 (35.8) | 82 (39.4) | 46 (38.3) | 36 (40.9) | | TLR2 (−16934) | A | 187 (51.1) | 115 (55.3) | 65 (54.2) | 50 (56.8) | | rs4696480 | T | 179 (48.9) | 93 (44.7) | 55 (45.8) | 38 (43.2) | | TLR2 (intron1) | A | 185 (50.5) | 112 (53.8) | 66 (55.0) | 46 (52.3) | | rs1898830 | G | 181 (49.5) | 96 (46.2) | 54 (45.0) | 42 (47.7) | | TLR2 (3UTR) | G | 180 (49.2) | 116 (55.8) | 70 (58.3) | 46 (52.3) | | rs7656411 | T | 186 (50.8) | 92 (44.2) | 50 (41.7) | 42 (47.7) | | TLR3 (c.1243) | A | 111 (30.3) | 59 (28.4) | 31 (25.8) | 28 (31.8) | | rs3775291 | G | 255 (69.7) | 149 (71.6) | 89 (74.2) | 60 (68.2) | | TLR3 (−7) | A | 80 (21.9) | 49 (23.6) | 24 (20.0) | 25 (28.4) | | rs3775296 | C | 286 (78.1) | 159 (76.4) | 96 (80.0) | 63 (71.6) | | TLR4 (3UTR) | C | 83 (22.7) | 49 (23.6) | 31 (25.8) | 18 (20.5) | | rs11536889 | G | 283 (77.3) | 159 (76.4) | 89 (74.2) | 70 (79.5) | | TLR4 (−1607) | C | 103 (28.1) | 47 (22.6) | 25 (20.8) | 22 (25.0) | | rs10759932 | T | 263 (71.9) | 161 (77.4) | 95 (79.2) | 66 (75.0) | | TLR4 (intron1) | C | 219 (59.8) | 135 (64.9) | 84 (70.0)a | 51 (58.0) | | rs1927911 | T | 147 (40.2) | 73 (35.1) | 36 (30.0) | 37 (42.0) | | CC-TLR5 (+1174) | C | 362 (98.9) | 205 (98.6) | 118 (98.3) | 87 (98.9) | | rs5744168 | T | 4 (1.1) | 3 (1.4) | 2 (1.7) | 1 (1.1) | | CC-TLR6 (+745) | C | 366 (100.0) | 208 (100.0) | 120 (100.0) | 88 (100.0) | | rs5743810 | G | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | | TLR6 (3UTR) | C | 180 (49.2) | 117 (56.3) | 66 (55.0) | 51 (58.0) | | rs2381289 | T | 186 (50.8) | 91 (43.7) | 54 (45.0) | 37 (42.0) | | TLR9 (+2848) | A | 150 (41.0) | 89 (42.8) | 50 (41.7) | 39 (44.3) | | rs352140 | G | 216 (59.0) | 119 (57.2) | 70 (58.3) | 49 (55.7) | | TLR9 (−1486) | C | 152 (41.5) | 91 (43.8) | 51 (42.5) | 40 (45.5) | | rs187084 | T | 214 (58.5) | 117 (56.2) | 69 (57.5) | 48 (54.5) | | TLR9 (3UTR) | C | 153 (41.8) | 90 (43.3) | 50 (41.7) | 40 (45.5) | | rs352162 | T | 213 (58.2) | 118 (56.7) | 70 (58.3) | 48 (54.5) |
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SNP: single-nucleotide polymorphism; AITD: autoimmune thyroid diseases; HD: Hashimoto’s disease; GD: Graves’ disease; TLR: Toll-like receptor. Controls versus GD: aOR = 1.56 (1.0–2.4), .
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