Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients

Table 4

Genotype frequencies of TLR4 genes between controls and patients with or without thyroid-associated ophthalmopathy in Graves’ disease.

		Normal	GD TAO	GD non-TAO
		(%)	(%)	(%)
TLR4 (intron1)	CC	63 (34.4)	15 (51.7)	17 (54.8)^b
rs1927911	CT	93 (50.8)	9 (31.0)^a	11 (35.5)
	TT	27 (14.8)	5 (17.2)	3 (9.7)
	C	219 (59.8)	39 (67.2)	45 (72.6)
	T	147 (40.2)	19 (32.8)	17 (27.4)
TLR9 (−1486)	CC	35 (19.1)	8 (27.6)	2 (6.5)^c
rs187084	CT	82 (44.8)	12 (41.4)	19 (61.3)
	TT	66 (36.1)	9 (31.0)	10 (32.3)
	C	152 (41.5)	28 (48.3)	23 (37.1)
	T	214 (58.5)	30 (51.7)	39 (62.9)

AITD: autoimmune thyroid diseases; GD: Graves’ disease; TAO: thyroid-associated ophthalmopathy. Controls versus TAO: ^aOR = 0.4 (0.18–1.00), ; controls versus non-TAO: ^bOR = 2.31 (1.07–4.99), ; TAO versus non-TAO: ^cOR = 5.52 (1.06–28.7), .