Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients

Table 5

Genotype frequencies of TLR4 genes between controls and female or male in GD.

		Normal	GD female	GD male
		(%)	(%)	(%)
TLR4 (−1607)	CC	17 (9.3)	0 (0.0)	4 (30.8)^d
rs10759932	CT	69 (37.7)	15 (31.9)	2 (15.4)
	TT	97 (53.0)	32 (68.1)	7 (53.8)
	C	103 (28.1)	15 (16.0)	10 (38.5)
	T	263 (71.9)	79 (84.0)^a	16 (61.5)
TLR4 (intron1)	CC	63 (34.4)	26 (55.3)^b	6 (46.2)
rs1927911	CT	93 (50.8)	18 (38.3)	2 (15.4)^e
	TT	27 (14.8)	3 (6.4)	5 (38.5)^f
	C	219 (59.8)	70 (74.5)^c	14 (53.8)
	T	147 (40.2)	24 (25.5)	12 (46.2)

AITD: autoimmune thyroid diseases; GD: Graves’ disease. Controls versus GD female: ^aOR = 2.06 (1.13–3.74), P = 0.015, Pc = 0.03; ^bOR = 2.36 (1.23–4.52), P = 0.008, Pc = 0.026; ^cOR = 1.96 (1.18–3.26), , Pc = 0.018; controls versus GD male: ^dOR = 4.34 (1.21–15.60), ; ^eOR = 0.18 (0.04–0.82), , Pc = 0.032; ^fOR = 3.61 (1.1–11.87), .