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International Journal of Endocrinology
Volume 2017 (2017), Article ID 2316986, 6 pages
Research Article

Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome

1Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland
2Department of Reproduction and Gynecological Endocrinology, Medical University of Białystok, Białystok, Poland

Correspondence should be addressed to Agnieszka Adamska

Received 21 January 2017; Revised 27 April 2017; Accepted 4 May 2017; Published 18 June 2017

Academic Editor: Amelie Bonnefond

Copyright © 2017 Agnieszka Adamska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance (IR). The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of IR and insulin secretion in women with PCOS, compared to the control group. Methods. The study group comprised 43 women with PCOS and 16 controls. IR was assessed by HOMA-IR and Matsuda index. Insulin secretion was evaluated with HOMA-B. An oral glucose tolerance test (OGTT) with estimation of serum betatrophin concentrations was performed. Results. Glucose load resulted in an increase in serum betatrophin concentrations in the control group (). Serum betatrophin concentrations at 120 min of OGTT were lower in women with PCOS than in the control group (). We observed positive correlations between baseline serum betatrophin concentrations and HOMA-IR (, ), negative correlations with Matsuda index (, ), and a positive relationship with HOMA-B (, ) in women with PCOS. Multiple regression analysis revealed that HOMA-B (, ) was an independent factor connected to serum betatrophin levels in PCOS. Conclusions. Serum concentrations of betatrophin are connected with insulin resistance and beta cell function and did not change after glucose load in women with PCOS.