The Proline 7 Substitution in the Preproneuropeptide Y Is Associated with Higher Hepatic Lipase Activity In Vivo

Figure 2

Sketch depicting the potential association between the Leu7Pro polymorphism and plasma HL activity: the presence of the SNP modifies the stress-induced release of NPY and factors of the sympathetic nervous system that are coregulated. Sympathetic action blocks HL maturation and secretion from the liver cells. HL secretion is indirectly stimulated by alpha1B-adrenergic inhibition.