Circulatory Immune Cells in Cushing Syndrome: Bystanders or Active Contributors to Atherometabolic Injury? A Study of Adhesion and Activation of Cell Surface Markers
Table 1
Characteristics of the study population.
Parameters
ACTH-dependent CS (n = 16)
ACTH-independent CS (n = 10)
Control (n = 16)
value
Age (years)
44.1 ± 13.5
43.8 ± 9.8
43.9 ± 10.3
0.869
Leukocytes (mm3)
9460.0 ± 2429.2
7508.7 ± 1329.8
5842.0 ± 1279.2
<0.001
Neutrophils (mm3)
6562.5 ± 2093.7
5062.5 ± 1329.8
3270.0 ± 960.4
<0.001
Lymphocytes (mm3)
2031.2 ± 710.6
1725.0 ± 549.6
1870.0 ± 533.4
0.522
Monocytes (mm3)
562.5 ± 224.7
425.0 ± 128.1
330.0 ± 94.8
0.008
T2D (%)
5 (31)
3 (30)
0 (0)
0.341
HTA (%)
8 (50)
5 (50)
0 (0)
0.145
DLP (%)
3 (19)
3(30)
0 (0)
0.271
Obesity (%)
8 (50)
5 (50)
1 (6)
0.215
BMI (kg/m2)
29.4 ± 5.1
29.2 ± 13.1
24.2 ± 4.2
0.339
Waist C (cm)
94.7 ± 14.1
94.2 ± 18.3
77.5 ± 11.7
0.037
WHR
0.90 ± 0.1
0.89 ± 0.1
0.71 ± 0.1
0.024
TC (mmol/l)
5.6 ± 0.8
5.5 ± 0.5
4.5 ± 0.5
0.020
TG (mmol/l)
1.4 ± 0.6
1.4 ± 0.5
0.9 ± 0.6
0.238
LDL-c (mmol/l)
3.4 ± 0.5
3.4 ± 0.6
2.5 ± 0.6
0.016
HDL-c (mmol/l)
1.5 ± 0.4
1.5 ± 0.3
1.7 ± 0.6
0.355
Hs-CRP (mg/dl)
0.36 ± 0.36
0.30 ± 0.31
0.02 ± 0.01
0.038
Glucose (mmol/l)
6.5 ± 2.7
6.1 ± 0.7
5.2 ± 0.6
0.268
HOMA-IR
3.80 ± 2.51
3.69 ± 2.23
2.89 ± 2.91
0.482
HbA1c (DCCT)
6.8 ± 1.9
6.6 ± 0.5
5.4 ± 0.2
0.076
UFC-24hs (mcg/24hs)
269.2 ± 114.8
257.7 ± 118.1
44.8 ± 12.6
0.029
ACTH (pg/ml)
68.4 ± 73.5
5.6 ± 1.4
33.5 ± 7.3
0.023
Data are expressed as mean ± standard deviation. Qualitative variables are expressed as percentages. BMI: body mass index; HOMA-IR: homeostasis model assessment for insulin resistance; T2D: type 2 diabetes; HbA1c (DCCT): haemoglobin A1c (diabetes control and complication trial units); Hs-CRP: high-sensitivity C-reactive protein; LDL-c: low-density lipoprotein cholesterol; HDL-c: high-density lipoprotein cholesterol; WHR: waist/hip ratio. ..
