The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules

Table 2

Demographic, ultrasonographic, and cytological results thyroid nodules; comparison of serum IGF-1; intranodular IGF-1, serum IGFBP-3, and intranodular IGFBP-3.

Clinic and laboratory features	Serum IGF-1 (ng/ml)	Intranodular IGF-1 (ng/ml)	Serum IGFBP-3 (μg/ml)	Intranodular IGFBP-3 (μg/ml)
<45 years ()	234.2 ± 10.6	37.7 (34.4–47.6)	4.8 (2.2–6.3)	0.173 (0.08–0.48)
>45 years ()	232.5 ± 13.6	39.1 (32.6–49.8)	4.9 (2.4–6.4)	0.173 (0.06–0.64)
	0.638	0.823	0.680	0.828
Female	234.6 ± 13.2	38.8 (33.7–49.8)	4.85 (2.2–6.3)	0.208 (0.07–0.64)
Male	227.5 ± 10.6	39.1 (32.6–48.7)	4.8 (3.8–6.4)	0.172 (0.07–0.50)
	0.028	0.969	0.768	0.876
Single [ (25%)]	229.5 ± 12.9	37.7 ± 2.6	4.8 (3.5–6.3)	0.14 (0.07–0.39)
Multinodular [ (75%)]	233.9 ± 12.9	40.7 ± 4.1	4.8 (2.2–6.4)	0.19 (0.07–0.64)
	0.191	0.001	0.841	0.043
Benign sonography	236.1 ± 13.7	40.05 ± 4.82	4.6 (2.4–6.3)	0.175 (0.07–0.5)
Sonography revealing suspected malignancy	231.5 ± 12.5	39.9 ± 3.7	4.9 (2.2–6.4)	0.173 (0.07–0.64)
	0.145	0.899	0.577	0.674
Hypoactive [ (22.5%)]	234.5 (212–278)	39.9 ± 3.6	5.05 (2.4–6.3)	0.17 (0.07–0.5)
Hyperactive [ (55%)]	230.5 (208–254)	40.2 ± 4.9	5.2 (2.2–6.4)	0.14 (0.07–0.64)
	0.545	0.773	0.895	0.187
Benign cytology (, 91.3%)	232.5 ± 12.9	39.1 (33.7–49.8)	4.8 (2.2–6.4)	0.173 (0.07–0.64)
Suspicious and malignant cytology (, 8.7%)	236.3 ± 13.9	37.9 (32.6–41.9)	5.4 (4.1–6)	0.173 (0.08–0.29)
	0.247	0.237	0.528	0.433
Histopathology
Benign ()	234 ± 11.3	40.7 ± 5.01		0.23 ± 0.15
Malign ()	234.5 ± 7.0	40.8 ± 2.29		0.169 ± 0.09
	0.983	0.966	0.436	0.477

Mann–Whitney U test. Student’s t-test.