Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves’ Ophthalmopathy
Table 1
Clinical features of each group.
Responsive ()
Unresponsive ()
Control ()
value
Age (years)
42.83 ± 12.28
44.33 ± 10.79
45.70 ± 13.66
0.83
Female (n, %)
11 (61.1%)
8 (53.3%)
6 (60.0%)
0.95
Smoking history
4 (22.2%)
3 (20%)
2 (20%)
0.99
Alcohol intake
2 (11.1%)
1 (6.7%)
1 (10%)
0.91
BMI
22.75 ± 2.11
24.57 ± 3.88
22.01 ± 1.27
0.06
SBP (mmHg)
133.11 ± 17.10
131.40 ± 17.15
132.30 ± 15.79
0.96
DBP (mmHg)
77.56 ± 10.22
83.40 ± 9.46
80.70 ± 10.76
0.26
ALT (U/L)
15.67 ± 7.74
20.56 ± 14.41
18.20 ± 5.16
0.40
AST (U/L)
20.39 ± 7.95
21.25 ± 8.03
21.90 ± 6.15
0.88
BUN (mmol/L)
4.70 ± 1.49
3.95 ± 0.96
4.53 ± 1.12
0.22
Cr (μmol/L)
55.89 ± 22.78
44.27 ± 15.46
56.30 ± 5.89
0.13
TG (mmol/L)
1.39 ± 0.70
1.50 ± 0.74
1.75 ± 0.69
0.48
TC (mmol/L)
4.85 ± 1.19
5.15 ± 1.49
4.69 ± 1.33
0.72
HDL (mmol/L)
1.24 ± 0.47
1.20 ± 0.37
1.10 ± 0.28
0.70
LDL (mmol/L)
2.86 ± 0.69
3.23 ± 1.11
2.81 ± 1.00
0.52
FT3 (pg/mL)
5.75 ± 6.31
4.23 ± 1.77
2.99 ± 0.39
0.25
FT4 (ng/dL)
1.62 ± 1.17
1.43 ± 0.54
1.15 ± 0.16
0.36
TSH (mUI/L)
0.468 (0.004–2.465)
0.070 (0.004–1.15)
2.330 (1.304–3.05)
0.02
TRAb (UI/L)
12.75 (5.78–27.20)
12.75 (5.59–22.09)
0.580 (0.320–0.650)
<0.001
Hyperthyroidism duration (months)
14 (7.25–25.5)
22 (12–42)
—
0.49
GO duration (months)
8.0 (3–12.25)
9.5 (4.0–12.5)
—
0.66
Antithyroid treatments
Antithyroid drug
6 (33.3%)
7 (46.7%)
—
0.44
Radioiodine
9 (50.0%)
6 (40.0%)
—
0.57
Thyroidectomy
3 (16.7%)
2 (13.3%)
—
0.79
CAS
4.56 ± 1.10
4.27 ± 1.03
—
0.45
Lid width (mm)
11.06 ± 1.12
10.67 ± 1.02
8.50 ± 0.86
<0.001
Visual acuity
0.80 ± 0.15
0.83 ± 0.18
0.99 ± 0.17
0.02
Diplopia
0.02
Absent
6 (33.3%)
4 (26.7%)
10 (100%)
Intermittent
5 (27.8%)
5 (33.3%)
0
Inconstant
4 (22.2%)
4 (26.7%)
0
Constant
3 (16.7%)
2 (13.3%)
0
; . TSH: responsive group versus unresponsive group, . TRAb: responsive group versus unresponsive group, . Lid width: responsive group versus unresponsive group, . Visual acuity: responsive group versus unresponsive group, . Diplopia: responsive group versus unresponsive group, .
