STK11 rs2075604 Polymorphism Is Associated with Metformin Efficacy in Chinese Type 2 Diabetes Mellitus

Table 1

Demographic and clinical characteristics of T2DM patients and healthy subjects.

Parameters	Healthy subjects; ()	T2DM patients; ()
Gender
Male	111	245	0.177
Female	89	155
Age (years)	56.88 ± 7.91	56.97 ± 12.65	0.925
BMI (kg/m^2)	22.68 ± 1.69	24.46 ± 2.28	0.000
HbA1c (%)	5.53 ± 2.84	7.75 ± 1.75	0.000
FBG (mmol/L)	5.37 ± 1.55	7.82 ± 2.53	0.000
PBG (mmol/L)	6.56 ± 2.97	15.22 ± 6.43	0.000
INS (uIU/mL)	5.80 (3.69, 9.67)	7.99 (4.35, 12.70)	0.000
CPO (ng/mL)	2.35 (1.81, 3.03)	1.89 (1.14, 2.75)	0.000
PCPO (ng/mL)	7.48 ± 4.01	5.45 ± 3.44	0.000
TC (mmol/L)	5.17 ± 4.45	4.75 ± 1.27	0.082
TG (mmol/L)	1.68 ± 3.85	1.91 ± 1.88	0.340
LDL (mmol/L)	2.67 (2.15, 3.15)	2.81 (2.08, 3.38)	0.267
HDL (mmol/L)	1.40 (1.19, 1.68)	1.09 (0.93, 1.32)	0.000

Data are shown as mean ± SD. Data was analyzed by two-sample t-test. Skewed data shown as median (quartiles). Data was analyzed by the Mann–Whitney U test. BMI: body mass index; HbA1c: glycosylated haemoglobin; FBG: fasting blood glucose; PBG: postprandial blood glucose; INS: insulin; CPO: C-peptide; PCPO: postprandial C-peptide; TC: total cholesterol; TG: triglycerides; LDL: low-density lipoprotein cholesterol; HDL: high-density lipoprotein cholesterol; T2DM: type 2 diabetes mellitus. The numbers in bold indicated statistically significant values.