STK11 rs2075604 Polymorphism Is Associated with Metformin Efficacy in Chinese Type 2 Diabetes Mellitus

Table 4

Association between STK11 rs2075604 genetic polymorphism and metformin efficacy in T2DM patients (adjusted for age, gender, and BMI).

rs2075604 (G>T)	Non-response ()	Response ()	OR (95% CI)
Genotypes
GG	18 (56.25%)	18 (29.03%)	1.0 (reference)	—
GT	11 (34.37%)	34 (54.84%)	3.091 (1.204–7.936)	0.019
TT	3 (9.38%)	10 (16.13%)	1.826 (0.886–3.762)	0.103
Alleles
G	47 (73.44%)	70 (56.45%)	1.0 (reference)	—
T	17 (26.56%)	54 (43.55%)	2.133 (1.104–4.121)	0.024
GG versus GT/TT (dominant model)			3.143 (1.293–7.638)	0.011
GG/GT versus TT (recessive model)			1.721 (0.430–6.888)	0.443

Data was analyzed by the logistic regression by adjusting for sex, age, and BMI. OR: odds ratio; CI: confidence interval. The numbers in bold indicated statistically significant values.