Research Article
Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease
Table 1
Clinical characteristics of AITD patients and controls.
| | Clinical phenotype | AITD (%) | GD (%) | HT (%) | Control (%) |
| | Number | 975 | 639 | 336 | 851 | | Gender | | Male | 233 (23.90) | 190 (29.73) | 43 (12.80) | 284 (33.37) | | Female | 742 (76.10) | 449 (70.27) | 293 (87.20) | 567 (66.63) | | Average age | 36.210 ± 14.345 | — | — | 38.700 ± 8.945 | | ≤18 years | 105 (10.77) | — | — | — | | With family history | 32 (30.48) | — | — | — | | ≥19 years | 870 (89.23) | — | — | — | | With family history | 108 (12.41) | — | — | — | | Age at diagnosis | 33.340 ± 14.160 | — | — | — | | Ophthalmopathy (+) | 118 (12.10) | 112 (17.53) | 6 (1.79) | — | | Family history (+) | 202 (20.72) | — | — | — | | Smoking history (+) | 291 (29.85) | — | — | — | | TRAb (+) | — | 639 (100.00) | — | — | | TPOAb (+) | — | — | 267 (79.53) | — | | TGAb (+) | — | — | 176 (52.30) | — | | Hypothyroidism | — | — | 171 (50.89) | — |
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AITD: autoimmune thyroid disease; GD: Graves’ disease; HT: Hashimoto’s thyroiditis.
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