Research Article
Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease
Table 2
Comparison of allele and genotype frequencies of IL-22 SNPs in AITD, GD, and HT patients and controls.
| | SNP ID | Groups | value (OR/95% CI) | | NC (%) | AITD (%) | GD (%) | HT (%) | AITD versus NC | GD versus NC | HT versus NC |
| | rs2046068 | | | AA | 559 (65.69) | 622 (63.79) | 419 (65.57) | 203 (60.42) | 0.495 | 0.67 | 0.211 | | CC | 31 (3.64) | 45 (4.62) | 29 (4.54) | 16 (4.76) | | | | | AC | 261 (30.67) | 308 (31.59) | 191 (29.89) | 117 (34.82) | | | | | A | 1379 (81.02) | 1552 (79.59) | 1029 (80.52) | 523 (77.83) | 0.278 (0.913/0.775–1.076) | 0.729 (0.968/0.805–1.163) | 0.079 (0.822/0.661–1.023) | | C | 323 (18.98) | 398 (20.41) | 249 (19.48) | 149 (22.17) | | | | | rs2227478 | | | TT | 558 (65.57) | 622 (63.80) | 418 (65.42) | 204 (60.72) | 0.609 | 0.828 | 0.271 | | CC | 32 (3.76) | 44 (4.51) | 28 (4.38) | 16 (4.76) | | | | | TC | 261 (30.67) | 309 (31.69) | 193 (30.20) | 116 (34.52) | | | | | T | 1377 (80.90) | 1553 (79.64) | 1029 (80.52) | 524 (77.98) | 0.339 (0.923/0.784–1.087) | 0.790 (0.975/0.812–1.172) | 0.108 (0.836/0.671–1.040) | | C | 325 (19.10) | 397 (20.36) | 249 (19.48) | 148 (22.02) | | | | | rs2227485 | | | CC | 246 (28.91) | 315 (32.31) | 200 (31.30) | 115 (34.23) | 0.219 | 0.508 | 0.162 | | TT | 196 (23.03) | 227 (23.28) | 150 (23.47) | 77 (22.92) | | | | | CT | 409 (48.06) | 433 (44.41) | 289 (45.23) | 144 (42.85) | | | | | C | 901 (52.94) | 1063 (54.51) | 689 (53.91) | 374 (55.65) | 0.341 (1.065/0.935–1.214) | 0.598 (1.040/0.899–1.203) | 0.232 (1.116/0.932–1.335) | | T | 801 (47.06) | 887 (45.49) | 589 (46.09) | 298 (44.35) | | | | | rs1179251 | | | CC | 354 (41.60) | 427 (43.79) | 278 (43.51) | 149 (44.35) | 0.179 | 0.226 | 0.432 | | GG | 85 (9.99) | 115 (11.80) | 77 (12.05) | 38 (11.31) | | | | | CG | 412 (48.41) | 433 (44.41) | 284 (44.44) | 149 (44.34) | | | | | C | 1120 (65.80) | 1287 (66.00) | 840 (65.73) | 447 (66.52) | 0.901 (1.009/0.879–1.157) | 0.965 (0.997/0.855–1.161) | 0.741 (1.032/0.855–1.247) | | G | 582 (34.20) | 663 (34.00) | 438 (34.27) | 225 (33.48) | | | | | rs11611206 | | | GG | 686 (80.61) | 782 (80.21) | 506 (79.19) | 276 (82.14) | 0.298 | 0.342 | 0.273 | | AA | 4 (0.47) | 11 (1.12) | 7 (1.09) | 4 (1.19) | | | | | GA | 161 (18.92) | 182 (18.67) | 126 (19.72) | 56 (16.67) | | | | | G | 1533 (90.07) | 1746 (89.54) | 1138 (89.05) | 608 (90.48) | 0.596 (0.944/0.761–1.170) | 0.364 (0.896/0.707–1.135) | 0.765 (1.047/0.774–1.417) | | A | 169 (9.93) | 204 (10.46) | 140 (10.95) | 64 (9.52) | | | |
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SNP: single-nucleotide polymorphism; AITD: autoimmune thyroid disease; GD: Graves’ disease; HT: Hashimoto’s thyroiditis; NC: normal controls; OR: odds ratio; CI: confidence interval.
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