Research Article
Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease
Table 3
Allele and genotype distribution of IL-22 SNPs in different sex groups of AITD patients.
| | Loci | Male | Female | | NC (%) | AITD (%) | value | OR/95% CI | NC (%) | AITD (%) | value | OR/95% CI |
| | rs2046068 | | | AA | 195 (68.66) | 147 (63.09) | 0.230 | | 364 (64.20) | 475 (64.02) | 0.955 | | | CC | 7 (2.47) | 11 (4.72) | | | 24 (4.23) | 34 (4.58) | | | | AC | 82 (28.87) | 75 (32.19) | | | 179 (31.57) | 233 (31.40) | | | | A | 472 (83.10) | 369 (79.18) | 0.108 | 0.774/0.566–1.058 | 907 (79.98) | 1183 (79.72) | 0.867 | 0.984/0.811–1.193 | | C | 96 (16.90) | 97 (20.82) | | | 227 (20.02) | 301 (20.28) | | | | rs2227478 | | | TT | 195 (68.66) | 148 (63.52) | 0.329 | | 363 (64.02) | 474 (63.88) | 0.982 | | | CC | 8 (2.82) | 11 (4.72) | | | 24 (4.23) | 33 (4.45) | | | | TC | 81 (28.52) | 74 (31.76) | | | 180 (31.75) | 235 (31.67) | | | | T | 471 (82.92) | 370 (79.40) | 0.148 | 0.794/0.580–1.086 | 906 (79.89) | 1183 (79.88) | 0.901 | 0.989/0.816–1.199 | | C | 97 (17.08) | 96 (20.60) | | | 228 (20.11) | 301 (20.28) | | | | rs2227485 | | | CC | 76 (26.76) | 64 (27.47) | 0.880 | | 170 (29.98) | 251 (33.83) | 0.171 | | | TT | 70 (24.65) | 53 (22.74) | | | 126 (22.22) | 174 (23.45) | | | | CT | 138 (48.59) | 116 (49.79) | | | 271 (47.80) | 317 (42.72) | | | | C | 290 (51.06) | 244 (52.36) | 0.676 | 1.054/0.825–1.346 | 611 (53.88) | 819 (55.19) | 0.505 | 1.054/0.903–1.231 | | T | 278 (48.94) | 222 (47.64) | | | 523 (46.12) | 665 (44.81) | | | | rs1179251 | | | CC | 119 (41.90) | 104 (44.63) | 0.449 | | 235 (41.45) | 323 (43.53) | 0.048 | | | GG | 31 (10.92) | 18 (7.73) | | | 54 (9.52) | 97 (13.07) | | | | CG | 134 (47.18) | 111 (47.64) | | | 278 (49.03) | 322 (43.40) | | | | C | 372 (65.49) | 319 (68.45) | 0.314 | 1.143/0.881–1.484 | 748 (65.96) | 968 (65.23) | 0.696 | 0.968/0.823–1.139 | | G | 196 (34.51) | 147 (31.55) | | | 386 (34.04) | 516 (34.77) | | | | rs11611206 | | | GG | 232 (81.69) | 184 (78.97) | 0.602 | | 454 (80.07) | 598 (80.59) | 0.387 | | | AA | 1 (0.35) | 2 (0.86) | | | 3 (0.53) | 9 (1.21) | | | | GA | 51 (17.96) | 47 (20.17) | | | 110 (19.40) | 135 (18.20) | | | | G | 515 (90.67) | 415 (89.06) | 0.391 | 0.837/0.558–1.256 | 1018 (89.77) | 1331 (89.69) | 0.946 | 0.991/0.768–1.279 | | A | 53 (9.33) | 51 (10.94) | | | 116 (10.23) | 153 (10.31) | | |
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. SNP: single-nucleotide polymorphism; AITD: autoimmune thyroid disease; NC: normal controls; OR: odds ratio; CI: confidence interval.
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