Research Article
Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease
Table 4
Allele and genotype analysis of IL-22 SNPs in male patients with HT.
| | Loci | Male | | NC (%) | HT (%) | value | OR/95% CI |
| | rs2046068 | | | AA | 195 (68.66) | 22 (51.16) | 0.084 | | | CC | 7 (2.47) | 2 (4.65) | | | | AC | 82 (28.87) | 19 (44.19) | | | | A | 472 (83.10) | 63 (73.26) | 0.027 | 0.557 (0.329–0.942) | | C | 96 (16.90) | 23 (26.74) | | | | rs2227478 | | | TT | 195 (68.66) | 22 (51.16) | 0.086 | | | CC | 8 (2.82) | 2 (4.65) | | | | TC | 81 (28.52) | 19 (44.19) | | | | T | 471 (82.92) | 63 (73.26) | 0.031 | 0.564 (0.334–0.954) | | C | 97 (17.08) | 23 (26.74) | | | | rs2227485 | | | CC | 76 (26.76) | 11 (25.58) | 0.984 | | | TT | 70 (24.65) | 11 (25.58) | | | | CT | 138 (48.59) | 21 (48.84) | | | | C | 290 (51.06) | 43 (50.00) | 0.855 | 0.959 (0.609–0.509) | | T | 278 (48.94) | 43 (50.00) | | | | rs1179251 | | | CC | 119 (41.90) | 23 (53.49) | 0.007 | | | GG | 31 (10.92) | 0 | | | | CG | 134 (47.18) | 20 (46.51) | | | | C | 372 (65.49) | 66 (76.74) | 0.039 | 1.739 (1.024–2.952) | | G | 196 (34.51) | 20 (23.26) | | | | rs11611206 | | | GG | 232 (81.69) | 33 (76.74) | 0.396 | | | AA | 1 (0.35) | 1 (2.33) | | | | GA | 51 (17.96) | 9 (20.93) | | | | G | 515 (90.67) | 75 (87.21) | 0.314 | 0.702 (0.351–1.403) | | A | 53 (9.33) | 11 (12.79) | | |
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. SNP: single-nucleotide polymorphism; HT: Hashimoto’s thyroiditis; NC: normal controls; OR: odds ratio; CI: confidence interval.
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