Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease

Table 5

Allele and genotype frequencies of IL-22 SNPs with onset age and ophthalmopathy in AITD patients.

SNP	Onset age of AITD patients			Ophthalmopathy
	≥19 (%)	≤18 (%)	value (OR/95% CI)	Without (%)	With (%)	value (OR/95% CI)
rs2046068
AA	556 (63.91)	66 (62.86)	0.034	547 (63.83)	75 (63.56)	0.758
CC	35 (4.02)	10 (9.52)		38 (4.43)	7 (5.93)
AC	279 (32.07)	29 (27.62)		272 (31.74)	36 (30.51)
A	1391 (79.94)	161 (76.67)	0.266 (0.824/0.586–1.159)	1366 (79.70)	186 (78.81)	0.752 (0.948/0.679–1.323)
C	349 (20.06)	49 (23.33)		348 (20.30)	50 (21.19)
rs2227478
TT	556 (63.91)	66 (62.86)	0.028	547 (63.83)	75 (63.56)	0.719
CC	34 (3.91)	10 (9.52)		37 (4.32)	7 (5.93)
TC	280 (32.18)	29 (27.62)		273 (31.85)	36 (30.51)
T	1392 (80.00)	161 (76.67)	0.257 (0.821/0.584–1.155)	1367 (79.75)	186 (78.81)	0.736 (0.944/0.676–1.318)
C	348 (20.00)	49 (23.33)		347 (20.25)	50 (21.19)
rs2227485
CC	287 (32.99)	28 (26.67)	0.421	279 (32.56)	36 (30.51)	0.904
TT	201 (23.10)	26 (24.76)		199 (23.22)	28 (23.73)
CT	382 (43.91)	51 (48.57)		379 (44.22)	54 (45.76)
C	956 (54.94)	107 (50.95)	0.273 (0.852/0.640–1.135)	937 (54.67)	126 (53.39)	0.712 (0.950/0.723–1.248)
T	784 (45.06)	103 (49.05)		777 (45.33)	110 (46.61)
rs1179251
CC	372 (42.76)	55 (52.38)	0.120	368 (42.94)	59 (50.00)	0.116
GG	107 (12.30)	8 (7.62)		98 (11.44)	17 (14.41)
CG	391 (44.94)	42 (40.00)		391 (45.62)	42 (35.59)
C	1135 (65.23)	152 (72.38)	0.039 (1.397/1.016–1.920)	1127 (65.75)	160 (67.80)	0.534 (1.097/0.820–1.466)
G	605 (34.77)	58 (27.62)		587 (34.25)	76 (32.20)
rs11611206
GG	694 (79.77)	88 (83.81)	0.386	696 (81.21)	86 (72.88)	0.023
AA	11 (1.26)	0 (0)		11 (1.28)	0 (0)
GA	165 (18.97)	17 (16.19)		150 (17.51)	32 (27.12)
G	1553 (89.25)	193 (91.90)	0.236 (1.367/0.814–2.296)	1542 (89.96)	204 (86.44)	0.097 (0.711/0.474–1.066)
A	187 (10.75)	17 (8.10)		172 (10.04)	32 (13.56)

. SNP: single nucleotide polymorphism; AITD: autoimmune thyroid disease; OR: odds ratio; CI: confidence interval.