Research Article
Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease
Table 5
Allele and genotype frequencies of IL-22 SNPs with onset age and ophthalmopathy in AITD patients.
| SNP | Onset age of AITD patients | Ophthalmopathy | ≥19 (%) | ≤18 (%) | value (OR/95% CI) | Without (%) | With (%) | value (OR/95% CI) |
| rs2046068 | | AA | 556 (63.91) | 66 (62.86) | 0.034 | 547 (63.83) | 75 (63.56) | 0.758 | CC | 35 (4.02) | 10 (9.52) | | 38 (4.43) | 7 (5.93) | | AC | 279 (32.07) | 29 (27.62) | | 272 (31.74) | 36 (30.51) | | A | 1391 (79.94) | 161 (76.67) | 0.266 (0.824/0.586–1.159) | 1366 (79.70) | 186 (78.81) | 0.752 (0.948/0.679–1.323) | C | 349 (20.06) | 49 (23.33) | | 348 (20.30) | 50 (21.19) | | rs2227478 | | TT | 556 (63.91) | 66 (62.86) | 0.028 | 547 (63.83) | 75 (63.56) | 0.719 | CC | 34 (3.91) | 10 (9.52) | | 37 (4.32) | 7 (5.93) | | TC | 280 (32.18) | 29 (27.62) | | 273 (31.85) | 36 (30.51) | | T | 1392 (80.00) | 161 (76.67) | 0.257 (0.821/0.584–1.155) | 1367 (79.75) | 186 (78.81) | 0.736 (0.944/0.676–1.318) | C | 348 (20.00) | 49 (23.33) | | 347 (20.25) | 50 (21.19) | | rs2227485 | | CC | 287 (32.99) | 28 (26.67) | 0.421 | 279 (32.56) | 36 (30.51) | 0.904 | TT | 201 (23.10) | 26 (24.76) | | 199 (23.22) | 28 (23.73) | | CT | 382 (43.91) | 51 (48.57) | | 379 (44.22) | 54 (45.76) | | C | 956 (54.94) | 107 (50.95) | 0.273 (0.852/0.640–1.135) | 937 (54.67) | 126 (53.39) | 0.712 (0.950/0.723–1.248) | T | 784 (45.06) | 103 (49.05) | | 777 (45.33) | 110 (46.61) | | rs1179251 | | CC | 372 (42.76) | 55 (52.38) | 0.120 | 368 (42.94) | 59 (50.00) | 0.116 | GG | 107 (12.30) | 8 (7.62) | | 98 (11.44) | 17 (14.41) | | CG | 391 (44.94) | 42 (40.00) | | 391 (45.62) | 42 (35.59) | | C | 1135 (65.23) | 152 (72.38) | 0.039 (1.397/1.016–1.920) | 1127 (65.75) | 160 (67.80) | 0.534 (1.097/0.820–1.466) | G | 605 (34.77) | 58 (27.62) | | 587 (34.25) | 76 (32.20) | | rs11611206 | | GG | 694 (79.77) | 88 (83.81) | 0.386 | 696 (81.21) | 86 (72.88) | 0.023 | AA | 11 (1.26) | 0 (0) | | 11 (1.28) | 0 (0) | | GA | 165 (18.97) | 17 (16.19) | | 150 (17.51) | 32 (27.12) | | G | 1553 (89.25) | 193 (91.90) | 0.236 (1.367/0.814–2.296) | 1542 (89.96) | 204 (86.44) | 0.097 (0.711/0.474–1.066) | A | 187 (10.75) | 17 (8.10) | | 172 (10.04) | 32 (13.56) | |
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. SNP: single nucleotide polymorphism; AITD: autoimmune thyroid disease; OR: odds ratio; CI: confidence interval.
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