Research Article
Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease
Table 6
Allele and genotype frequencies of IL-22 SNPs with ophthalmopathy in GD patients and hypothyroidism in HT patients.
| | SNP loci | Ophthalmopathy in GD | Hypothyroidism in HT | | Without (%) | With (%) | value (OR/95% CI) | Without (%) | With (%) | value (OR/95% CI) |
| | rs2046068 | | | AA | 348 (66.03) | 71 (63.39) | 0.611 | 100 (60.61) | 103 (60.23) | 0.818 | | CC | 22 (4.18) | 7 (6.25) | | 9 (5.45) | 7 (4.09) | | | AC | 157 (29.79) | 34 (30.36) | | 56 (33.94) | 61 (35.68) | | | A | 853 (80.93) | 176 (78.57) | 0.418 (0.864/0.606–1.231) | 256 (77.58) | 267 (78.07) | 0.877 (1.029/0.715–1.481) | | C | 201 (19.07) | 48 (21.43) | | 74 (22.42) | 75 (21.93) | | | rs2227478 | | | TT | 347 (65.84) | 71 (63.39) | 0.558 | 101 (61.21) | 103 (60.23) | 0.789 | | CC | 21 (3.98) | 7 (6.25) | | 9 (5.46) | 7 (4.09) | | | TC | 159 (30.18) | 34 (30.36) | | 55 (33.33) | 61 (35.68) | | | T | 853 (80.93) | 176 (78.57) | 0.418 (0.864/0.606–1.231) | 257 (77.88) | 267 (78.07) | 0.952 (1.011/0.702–1.457) | | C | 201 (19.07) | 48 (21.43) | | 73 (22.12) | 75 (21.93) | | | rs2227485 | | | CC | 166 (31.50) | 34 (30.36) | 0.958 | 65 (39.39) | 50 (29.24) | 0.139 | | TT | 124 (23.53) | 26 (23.21) | | 36 (21.82) | 41 (23.98) | | | CT | 237 (44.97) | 52 (46.43) | | 64 (38.79) | 80 (46.78) | | | C | 569 (53.98) | 120 (53.57) | 0.910 (0.984/0.737–1.313) | 194 (58.79) | 180 (52.63) | 0.108 (0.779/0.574–1.057) | | T | 485 (46.02) | 104 (46.43) | | 136 (41.21) | 162 (47.37) | | | rs1179251 | | | CC | 221 (41.94) | 57 (50.89) | 0.045 | 69 (41.82) | 80 (46.78) | 0.173 | | GG | 60 (11.38) | 17 (15.18) | | 24 (14.54) | 14 (8.19) | | | CG | 246 (46.68) | 38 (33.93) | | 72 (43.64) | 77 (45.03) | | | C | 688 (65.28) | 152 (67.86) | 0.460 (1.123/0.826–1.528) | 210 (63.64) | 237 (69.30) | 0.120 (1.290/0.936–1.778) | | G | 366 (34.72) | 72 (32.14) | | 120 (36.36) | 105 (30.70) | | | rs11611206 | | | GG | 425 (80.65) | 81 (72.32) | 0.036 | 128 (77.57) | 148 (86.55) | 0.086 | | AA | 7 (1.33) | 0 (0) | | 3 (1.82) | 1 (0.58) | | | GA | 95 (18.02) | 31 (27.68) | | 34 (20.61) | 22 (12.87) | | | G | 945 (89.66) | 193 (86.16) | 0.128 (0.718/0.468–1.102) | 290 (87.88) | 318 (92.98) | 0.024 (1.828/1.075–3.106) | | A | 109 (10.34) | 31 (13.84) | | 40 (12.12) | 24 (7.02) | |
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. SNP: single nucleotide polymorphism; GD: Graves’ disease; HT: Hashimoto’s thyroiditis; OR: odds ratio; CI: confidence interval.
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