Clinical Presentation, Management, and Outcomes of Primary Hyperparathyroidism during Pregnancy

Table 1

Summary of clinical information of patients with pHPT during pregnancy.

Number

Age at presentation (years)

Gestation (weeks)

Symptoms

Obstetric history

Complications

Hypercalcaemic crisis

Eclampsia

Tumour size (diameter, cm)

Maternal serum iPTH (pg/mL)

Maternal serum ionized calcium (mmol/L)

Fetal outcome

Pathological result

(1)

37

7

None

G5P1A3

No

No

No

/

137

1.34

Normal

/

(2)

31

25

None

G1P0

No

No

No

2.9

213

1.79

Normal

Atypical adenoma

(3)

28

11

Nausea and vomiting

G1P0

No

No

No

2

162

1.75

Normal

Atypical adenoma

(4)

29

5

Nausea and vomiting

G1P0

No

No

No

1.5

139

1.73

Normal twins

Adenoma

(5)

32

27

Abdominal pain, diarrhoea, and loss of consciousness

G1P0

Acute pancreatitis, nephrolithiasis, and gestational hypertension

Yes

No

1.8

514

2.29

Artificial abortion

Adenoma

(6)

22

24

Headache and loss of consciousness

G1P0

Gestational hypertension

No

Yes

2.6

446

1.63

Artificial abortion

Adenoma

(7)

35

18

Nausea and vomiting

G2P0A1

Nephrolithiasis

Yes

No

3.1

634

3.07

Artificial abortion

Adenoma

(8)

34

6

Vomitingand loss of consciousness

G6P1A4

Nephrolithiasis

Yes

No

4.8

1776

3.15

Artificial abortion

Adenoma

(9)

26

Postpartum

None

G1P1

No

No

No

1.9

280

1.39

Hypocalcaemic tetany

Hyperplasia

(10)

28

Postpartum

No

G1P1

No

No

No

1.6

702

1.47

Hypocalcaemic tetany

Adenoma

(11)

26

Postpartum

Backache and vomiting

G1P1

Nephrolithiasis and gestational hypertension

No

No

2.7

333

1.48

Hypocalcaemic tetany

Adenoma

(12)

29

Postpartum

No

G1P1

No

No

No

3.1

139

1.36

Hypocalcaemic tetany

Adenocarcinoma