Table 3: Markers of PTH and calcium metabolism before and after lisinopril intervention; primary HPT, without HPT, and total cohort.

PreinterventionPostinterventionDelta value

Primary HPT,
PTH, pg/mL79.5 (21.6)70.9 (19.6)−8.60.049
Serum total calcium, mg/dL10.6 (0.5)10.5 (0.4)−0.050.48
Ionized calcium, mmol/L1.38 (0.06)1.37 (0.04)−0.0090.51
24-hour urinary calcium excretion, mg/day310.6 (80.8)324.8 (100.1)+14.20.51
24-hour urine phosphate excretion, mg/day998.4 (338.0)975.7 (454.5)−22.70.84
Without primary HPT,
PTH, pg/mL33.3 (25.4)32.5 (16.7)−0.780.80
Serum total calcium, mg/dL9.4 (0.4)9.5 (0.3)+0.030.80
Ionized calcium, mmol/L1.21 (0.07)1.21 (0.07)−01.0
24-hour urinary calcium excretion, mg/day171.0 (90.6)153.2 (70.4)−17.80.34
24-hour urine phosphate excretion, mg/day681.8 (406.9)597.9 (241.6)−165.40.26
Total cohort,
PTH, pg/mL53.8 (33.0)49.6 (26.3)−4.20.10
Serum total calcium, mg/dL9.9 (0.7)9.9 (0.6)−0.0040.96
Ionized calcium, mmol/L1.29 (0.10)1.28 (0.10)−0.0070.60
24-hour urinary calcium excretion, mg/day233.0 (110.4)229.4 (120.2)−3.600.80
24-hour urine phosphate excretion, mg/day822.5 (404.0)765.8 (394.2)−56.70.37

Values are mean (SD) unless otherwise noted. values are paired t-tests. HPT: hyperparathyroidism; PTH: parathyroid hormone.