Clinical Study
Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion
Table 3
Markers of PTH and calcium metabolism before and after lisinopril intervention; primary HPT, without HPT, and total cohort.
| | Preintervention | Postintervention | Delta | value |
| | Primary HPT, | | PTH, pg/mL | 79.5 (21.6) | 70.9 (19.6) | −8.6 | 0.049 | | Serum total calcium, mg/dL | 10.6 (0.5) | 10.5 (0.4) | −0.05 | 0.48 | | Ionized calcium, mmol/L | 1.38 (0.06) | 1.37 (0.04) | −0.009 | 0.51 | | 24-hour urinary calcium excretion, mg/day | 310.6 (80.8) | 324.8 (100.1) | +14.2 | 0.51 | | 24-hour urine phosphate excretion, mg/day | 998.4 (338.0) | 975.7 (454.5) | −22.7 | 0.84 | | Without primary HPT, | | PTH, pg/mL | 33.3 (25.4) | 32.5 (16.7) | −0.78 | 0.80 | | Serum total calcium, mg/dL | 9.4 (0.4) | 9.5 (0.3) | +0.03 | 0.80 | | Ionized calcium, mmol/L | 1.21 (0.07) | 1.21 (0.07) | −0 | 1.0 | | 24-hour urinary calcium excretion, mg/day | 171.0 (90.6) | 153.2 (70.4) | −17.8 | 0.34 | | 24-hour urine phosphate excretion, mg/day | 681.8 (406.9) | 597.9 (241.6) | −165.4 | 0.26 | | Total cohort, | | PTH, pg/mL | 53.8 (33.0) | 49.6 (26.3) | −4.2 | 0.10 | | Serum total calcium, mg/dL | 9.9 (0.7) | 9.9 (0.6) | −0.004 | 0.96 | | Ionized calcium, mmol/L | 1.29 (0.10) | 1.28 (0.10) | −0.007 | 0.60 | | 24-hour urinary calcium excretion, mg/day | 233.0 (110.4) | 229.4 (120.2) | −3.60 | 0.80 | | 24-hour urine phosphate excretion, mg/day | 822.5 (404.0) | 765.8 (394.2) | −56.7 | 0.37 |
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Values are mean (SD) unless otherwise noted. values are paired t-tests. HPT: hyperparathyroidism; PTH: parathyroid hormone.
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