Research Article
Therapeutic Outcomes of Patients with Multifocal Papillary Thyroid Microcarcinomas and Larger Tumors
Table 2
Clinical features of multifocal papillary thyroid cancer in different tumor sizes.
| | Clinical characteristics | All patients | Tumor | Tumor | value |
| | Patient number | 626 (100.0) | 147 (23.5) | 479 (76.5) | | | Gender, female | 499 (79.7) | 116 (78.9) | 383 (80.0) | 0.783 | | Age at diagnosis (year) | 46.5 ± 13.5 | 47.1 ± 11.4 | 46.3 ± 14.1 | 0.541 | | | 355 (56.7) | 90 (61.2) | 265 (55.3) | 0.207 | | 1-month postoperative serum Tg level (ng/mL) | 184.2 ± 1551.1 | 296.5 ± 2725.5 | 150.3 ± 941.6 | 0.331 | | Operative method | | Total thyroidectomy | 595 (95.0) | 130 (88.4) | 465 (97.1) | <0.001 | | TNM stage | | Stage I | 390 (62.3) | 122 (83.0) | 268 (55.9) | <0.001 | | Stages II–IV | 236 (37.7) | 25 (17.0) | 211 (44.1) | | | Nonremission | 131 (20.9) | 18 (12.2) | 113 (23.6) | 0.003 | | Residual | 83 (13.3) | 13 (8.8) | 70 (14.6) | 0.071 | | Relapsed | 48 (7.7) | 5 (3.4) | 43 (9.0) | 0.026 | | Follow-up period (year) | 7.1 ± 5.3 | 6.6 ± 5.1 | 7.2 ± 5.4 | 0.245 | | Postoperative 131I accumulative dose (mCi) [range] | 153.7 ± 222.2 [0.0–2050.0] | 114.3 ± 176.7 [0.0–1350.0] | 165.9 ± 233.0 [0.0–2050.0] | 0.014 | | | 569 (90.9) | 127 (86.4) | 442 (92.3) | 0.030 | | | 57 (9.1) | 20 (13.6) | 37 (7.7) | | | Radiation therapy | 28 (4.5) | 5 (3.4) | 23 (4.8) | 0.472 | | 2nd primary cancer | 49 (7.8) | 11 (7.5) | 38 (7.9) | 0.859 | | Diabetes mellitus | 61 (9.7) | 12 (8.2) | 49 (10.2) | 0.460 | | Overall mortality | 49 (7.8) | 8 (5.4) | 41 (8.6) | 0.218 | | Cancer mortality | 25 (4.0) | 4 (2.7) | 21 (4.4) | 0.368 | | Disease-free | 221 (35.3) | 58 (39.5) | 163 (34.0) | 0.228 | | Lymph node metastasis | 197 (31.5) | 33 (22.4) | 164 (34.2) | 0.007 | | Soft tissue invasion | 153 (24.4) | 14 (9.5) | 139 (29.0) | <0.001 | | Distant metastasis | 39 (6.2) | 5 (3.4) | 34 (7.1) | 0.105 |
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Number (%); mean ± SD.
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